TY  - JOUR
T1  - Assessment of the Effects of Prolonged Ginkgo biloba Extract Therapy on Hepatocellular Carcinoma Using Network Analysis
A1  - Giulia Romano
A1  - Marco Bianchi
A1  - Paolo Conti
JF  - Specialty Journal of Pharmacognosy, Phytochemistry, and Biotechnology
JO  - Spec J Pharmacogn Phytochem Biotechnol
SN  - 3062-441X
Y1  - 2021
VL  - 1
IS  - 1
DO  - 10.51847/kOYkele72O
SP  - 186
EP  - 193
N2  - Extracts from Ginkgo biloba have been widely utilized in therapeutic applications for managing various conditions, including malignancies, cardiovascular issues, and neurological disorders. Given the potential adverse reactions linked to prolonged use of G. biloba extract, this study examined gene expression patterns in the livers of mice subjected to extended treatment through analysis of protein-protein interaction (PPI) networks. Information regarding the impact of G. biloba on mouse liver was obtained from the Gene Expression Omnibus (GEO) repository. Gene expression data from three sample categories—healthy controls, spontaneous hepatocellular carcinoma (HCC), and those exposed to G. biloba extract—were contrasted. Differentially expressed genes (DEGs) were evaluated using directed PPI networks to identify pivotal regulatory genes. In total, 23 key regulatory genes were linked to the administration of G. biloba extract. The evaluation revealed that Rhoc, Myc, Cdc20, Cdk1, Plk1, Bub1, Aurkb, Bub1b, Gsk3b, Incenp, Sgol2a, Rbl1, Aurka, Mapk7, and Ccnd1 were connected to hepatocellular carcinoma. The other significant regulatory genes were implicated in malignancies and additional pathologies. Rhoc and Myc emerged as central genes associated with extended intake of G. biloba extract. These results highlight a strong association between chronic exposure to G. biloba extract and elevated cancer risks, particularly hepatocellular carcinoma.
UR  - https://galaxypub.co/article/assessment-of-the-effects-of-prolonged-ginkgo-biloba-extract-therapy-on-hepatocellular-carcinoma-usi-lxbkj2a49i7g6fn
ER  -