TY  - JOUR
T1  - Cardioprotective Effects of 6-Gingerol on Hypertrophic Cardiomyopathy in Diabetic Rats Induced by a High-Fat Diet and Low-Dose Streptozotocin
A1  - Wei Chen
A1  - Li Zhang
A1  - Qiang Sun
JF  - Specialty Journal of Pharmacognosy, Phytochemistry, and Biotechnology
JO  - Spec J Pharmacogn Phytochem Biotechnol
SN  - 3062-441X
Y1  - 2021
VL  - 1
IS  - 1
DO  - 10.51847/1uBNh2vx6y
SP  - 175
EP  - 185
N2  - Hypertrophic cardiomyopathy (HCM) associated with diabetes mellitus (DM) contributes significantly to elevated mortality rates. Previous studies have demonstrated that 6-gingerol mitigates HCM through attenuation of oxidative stress and inflammatory responses. This research explored the mechanisms involved, with particular emphasis on the AMPK/PGC-1α/SIRT1 signaling cascade, to assess its potential as a treatment option. Male Sprague-Dawley rats were fed a high-fat diet combined with high-fructose water for 16 weeks, followed by a single low-dose intraperitoneal injection of streptozotocin (22 mg/kg) to induce diabetes. Starting from week 8, the diabetic animals received oral administration of 6-gingerol at 50, 100, or 200 mg/kg body weight daily for 8 weeks. Cardiac tissue morphology was evaluated using histopathology. Protein levels of AMPK/PGC-1α/SIRT1 were measured via Western blot analysis, while ELISA quantified components of insulin signaling, glutathione peroxidase (GPx) activity, tumor necrosis factor-α (TNF-α), and cardiac troponin I (cTnI). Colorimetric assays determined malondialdehyde (MDA) and creatine kinase MB (CK-MB) concentrations. Administration of 6-gingerol at 200 mg/kg/day effectively reduced HCM features in diabetic rats, increased expression of AMPK/PGC-1α/SIRT1 proteins and insulin signaling components, and lowered cTnI and CK-MB concentrations. Additionally, it improved antioxidant defense by elevating GPx activity and reducing MDA and TNF-α levels. The results indicate that daily oral doses of 6-gingerol (50, 100, and 200 mg/kg) can mitigate diabetes-related HCM, potentially through enhancement of the AMPK/PGC-1α/SIRT1 axis and restoration of insulin signaling pathways.
UR  - https://galaxypub.co/article/cardioprotective-effects-of-6-gingerol-on-hypertrophic-cardiomyopathy-in-diabetic-rats-induced-by-a-fpw43s46sfalnoy
ER  -