TY  - JOUR
T1  - Clinical Aspects and Management of Klinefelter Syndrome in the Pediatric Age Group
A1  - Asma Ayed Alanazi
A1  - Fahad Abdullah Wajdi
A1  - Mohammed Saleh Al Issa
A1  - Albandari Abdulrahman Fallatah
A1  - Abdulrazaq Oudah Shaker
A1  - Abeer Abdalaziz Al Hatim
A1  - Mona Khalid Alqubali
A1  - Reem Hamoud Alshammari
A1  - Buthaynah Abdullah Alghasham
A1  - Hassan Yousef Almohammedali
A1  - Hanan Abdullah Alrashidi
A1  - Mohammed Anwar S Bawazier
JF  - Interdisciplinary Research in Medical Sciences Specialty
JO  - Interdiscip Res Med Sci Spec
SN  - 3062-4401
Y1  - 2022
VL  - 2
IS  - 1
DO  - 10.51847/EVNuxMoCMg
SP  - 15
EP  - 20
N2  - Klinefelter syndrome is the most common sex chromosome anomaly, occurring in approximately 1 in 660 males, yet fewer than 30% of individuals are diagnosed. This low diagnosis rate is due to the wide variability in the phenotypic presentation of the condition. The failure to detect Klinefelter syndrome early can lead to significant health complications, including primary hypogonadism, infertility, and an elevated risk of various cancers and other systemic diseases. This study aimed to review the existing literature on Klinefelter syndrome, focusing on its clinical features and its management in the pediatric population. Articles were selected and reviewed from the PubMed database. Klinefelter syndrome manifests in a wide range of clinical presentations that vary based on the age of the patient and the severity of the disease. During infancy, most cases appear phenotypically normal, although extreme cases may present with conditions such as microphallus and undescended testes. As children approach puberty, the rate of diagnosis increases due to the insufficient development of typical pubertal features, such as virilization and muscle mass. Many cases remain undiagnosed until adulthood, usually when individuals seek medical help for infertility. Management strategies include testosterone replacement therapy, assisted reproductive techniques, and early intervention to address associated complications.
UR  - https://galaxypub.co/article/clinical-aspects-and-management-of-klinefelter-syndrome-in-the-pediatric-age-group-56fgbp9d5dzm4tb
ER  -