%0 Journal Article
%T Comparison of Chicory–Fumitory Syrup and Megestrol for the Management of Hot Flashes in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy
%A Nguyen Thi Lan
%A Tran Minh Duc
%A Pham Hoang Anh
%J Specialty Journal of Pharmacognosy, Phytochemistry, and Biotechnology
%@ 3062-441X
%D 2024
%V 4
%N 1
%R 10.51847/z0Yjxkddqs
%P 264-275
%X Hot flashes rank as one of the most frequent and disruptive adverse reactions to androgen deprivation therapy (ADT) among men treated for prostate cancer. In the absence of an established standard therapy, more studies are needed to establish safe and effective management options. This randomized controlled trial involved prostate cancer patients on ADT who were randomly assigned to receive either chicory-fumitory syrup (derived from hydroalcoholic extracts of chicory and fumitory) or megestrol. Subjects logged the daily frequency and intensity of hot flashes for one week before starting treatment (baseline). They then took the assigned intervention—syrup (5 mL twice daily) or megestrol (20 mg twice daily)—for four weeks while maintaining the diary. The study was completed by 69 participants (35 in the chicory-fumitory arm and 34 in the megestrol arm). After four weeks, the chicory-fumitory group experienced a 38.19% reduction in mean daily hot flash frequency (p=0.004) and a 44.39% drop in hot flash score (p=0.008). The megestrol group showed a 68.93% decline in frequency (p
%U https://galaxypub.co/article/comparison-of-chicoryfumitory-syrup-and-megestrol-for-the-management-of-hot-flashes-in-prostate-can-aigzw7rqbtamoso