TY  - JOUR
T1  - Comprehensive Review on the Anticancer Potential of Thiazolidin-4-One Derivatives
A1  - Dalbir Singh
A1  - Mona Piplani
A1  - Harsha Kharkwal
A1  - Sankaranarayanan Murugesan
A1  - Yogendra Singh
A1  - Amit Aggarwal
A1  - Subhash Chander
JF  - Asian journal of Current Research in Clinical Cancer
JO  - Asian J Curr Res Clin Cancer
SN  - 3062-4444
Y1  - 2023
VL  - 3
IS  - 1
DO  - 10.51847/MpJ9fZKGZT
SP  - 46
EP  - 62
N2  - Thiazolidin-4-ones exhibit a highly adaptable and privileged core structure, consisting of a five-membered heterocyclic ring with a sulfur atom and a cyclic amide bond. Recent research, especially in the last decade, has extensively explored the various biological activities of this scaffold, highlighting its potential therapeutic applications. Several key features, such as drug-likeness, compatibility for diversity-oriented synthesis, and sensitivity to the redox environment of tumors, make it a promising structure for the development of anticancer agents. The thiazolidine-2,4-dione and thiazolidine-4-one are two classical forms of this scaffold, with the former receiving more attention compared to the latter. However, the thiazolidine-4-one core is increasingly attracting research interest, as reflected in numerous studies published in recent years. This comprehensive review primarily focuses on the anticancer potential of thiazolidine-4-one derivatives, exploring the structural variety and substitution patterns of compounds that feature this nucleus. The review explores the various enzymatic targets involved in drug discovery, highlighting their selectivity for cancerous tissues over healthy cells, as well as the structure-activity relationships (SAR). Future research perspectives are also discussed, with an emphasis on advancing translational studies. Further studies on pharmacokinetics and metabolic stability are recommended to move toward potential lead candidates for clinical application.
UR  - https://galaxypub.co/article/comprehensive-review-on-the-anticancer-potential-of-thiazolidin-4-one-derivatives-45wcobxntvhwqa3
ER  -