TY  - JOUR
T1  - Elucidating the Molecular Mechanisms of Jinhong Tablets for Chronic Superficial Gastritis through Chemical Profiling and Symptom-Oriented Network Pharmacology Analysis
A1  - Olivia Chen
A1  - Liam O'Connell
A1  - Noah Schmidt
JF  - Annals of Pharmacy Practice and Pharmacotherapy
JO  - Ann Pharm Pract Pharmacother
SN  - 3062-4436
Y1  - 2021
VL  - 1
IS  - 1
DO  - 10.51847/TujPcvi1bS
SP  - 65
EP  - 79
N2  - Chronic superficial gastritis (CSG) is a widespread digestive disorder with a complex and multifactorial pathogenesis. Jinhong tablet (JHT), a traditional Chinese medicine formulation, has shown efficacy in treating CSG, but the molecular mechanisms underlying its therapeutic effects remain poorly understood. In this study, we applied ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q/TOF-MS) to comprehensively profile the chemical composition of JHT. In total, 96 compounds were detected, of which 31 were validated using reference standards. Integrating these findings with symptom-oriented network pharmacology analyses—including “chi,” “blood,” “pain,” and “inflammation”—and evaluating compound-target interaction probabilities, we identified matrix metalloproteinase 2 (MMP2), dopamine D2 receptor (DRD2), and Aldo-keto reductase family 1 member B1 (AKR1B1) as central molecular targets for JHT’s action against CSG. Additionally, bioactive components belonging to alkaloids, flavonoids, and organic acids—such as chlorogenic acid (10), caffeic acid (13), (−)-corydalmine (33), (−)-isocorypalmine (36), isochlorogenic acids A, B, and C (38, 41, 47), quercetin-3-O-α-l-rhamnoside (42), quercetin (63), and kaempferol (70)—were found to exhibit notable inhibitory effects, supported by literature and molecular binding analyses. Overall, this study systematically mapped the chemical constituents of JHT and uncovered its symptom-guided molecular mechanisms in the treatment of CSG.
UR  - https://galaxypub.co/article/elucidating-the-molecular-mechanisms-of-jinhong-tablets-for-chronic-superficial-gastritis-through-ch-jiakaobsp7wnphd
ER  -