TY  - JOUR
T1  - Epidemiology and Pathology of Granulosa Cell Tumors: Insights from Nine Ovarian Tumor Cases
A1  - Imane Boujguenna
A1  - Fatima Ezzahra Ghlalou
A1  - Anass Fakhri
A1  - Abderraouf Soummani
A1  - Hanane Rais
JF  - Asian journal of Current Research in Clinical Cancer
JO  - Asian J Curr Res Clin Cancer
SN  - 3062-4444
Y1  - 2023
VL  - 3
IS  - 2
DO  - 10.51847/odRH4b5uDo
SP  - 32
EP  - 35
N2  - Granulosa cell tumors are malignant neoplasms that arise from the sexual cords and ovarian stroma. This study reviews the characteristics of 9 cases of granulosa cell tumors, with findings drawn from the existing literature. Among the cases, eight patients had adult-type granulosa tumors, while one patient had the juvenile form. The age of the patients ranged from 29 to 75 years, with a predominance of postmenopausal women (77.77%). The most common presenting symptoms were abdominal-pelvic pain (77.77%) and abdominal-pelvic masses (55.55%), followed by endocrine symptoms such as metrorrhagia (22.22%), and dysuria in one patient. Histologically, most cases showed typical microscopic features, including a diffuse tumor proliferation pattern with nuclear grooves present in all cases and Call-Exner bodies observed in two-thirds of cases. Surgical resection is the primary treatment approach, with the extent of surgery guided by the tumor stage and the patient’s overall health status. Although adjuvant chemotherapy and/or radiation may be used in certain cases, the optimal treatment strategy remains unclear due to the rarity of these tumors and the absence of large-scale clinical studies.
UR  - https://galaxypub.co/article/epidemiology-and-pathology-of-granulosa-cell-tumors-insights-from-nine-ovarian-tumor-cases-0vfwi45fgwjzkzf
ER  -