%0 Journal Article
%T Evaluating the Clinical Utility and Policy Impact of Next-Generation Sequencing Panel Testing under Japan’s Universal Health-Care System: A Retrospective Study from a University Hospital
%A M. R. Islam
%A N. Rahman
%A S. Hoque
%J Asian Journal of Current Research in Clinical Cancer
%@ 3062-4444
%D 2022
%V 2
%N 1
%R 10.51847/g3xO66htrx
%P 74-83
%X Next-generation sequencing (NGS) has been integrated into routine cancer care in Japan, supported by coverage from the national universal health-care system. However, this reimbursement currently applies only to patients who have completed standard therapeutic options. In this retrospective analysis, we reviewed data from 221 individuals who received the Foundation One CDx (F1CDx) test at our university hospital. Each patient’s sequencing results were evaluated by a molecular tumor board (MTB) to determine possible targeted treatment strategies. When patients consented, the MTB also reviewed potential germline variants, which were later disclosed during follow-up consultations. Among the total cases, 204 patients successfully underwent testing, and 195 results were analyzed. Due to disease progression, 13.8% of patients were unable to receive their reports. Of the 168 individuals who reviewed their results, 41.6% showed at least one actionable genomic alteration, and 3.6% received therapies matched to their genetic profiles. Presumed germline variants were identified in 24 patients, with 16.7% choosing to consult a genetics counselor.

Our findings indicate that performing NGS earlier in a patient’s treatment timeline could enhance its clinical value. Broader insurance coverage for NGS testing would likely improve access to precision oncology and increase opportunities for matched therapies. Moreover, incorporating the disclosure of suspected germline variants appears to be a practical approach in daily clinical settings.
%U https://galaxypub.co/article/evaluating-the-clinical-utility-and-policy-impact-of-next-generation-sequencing-panel-testing-under-rj3xtpfgel5e25i