TY  - JOUR
T1  - From cN+ to ycN0: Sentinel Node Biopsy as a Safe Alternative to ALND Post-Neo-Adjuvant Chemotherapy
A1  - A. Nurpeisov
A1  - D. Omarova
A1  - B. Kairat
JF  - Asian Journal of Current Research in Clinical Cancer
JO  - Asian J Curr Res Clin Cancer
SN  - 3062-4444
Y1  - 2024
VL  - 4
IS  - 2
DO  - 10.51847/y5XCZ7swz1
SP  - 74
EP  - 82
N2  - Sentinel lymph node biopsy (SLNB) has largely replaced axillary lymph node dissection (ALND) for breast cancer (BC) patients receiving neo-adjuvant chemotherapy (NAC). It is routinely used in individuals who present with clinically node-negative (cN0) disease, but its value in those who begin as clinically node-positive (cN+) remains unsettled. We retrospectively reviewed BC cases treated with NAC followed by SLNB to determine the relevance of this approach. Clinical features and oncologic outcomes were contrasted between patients who were cN0 or cN+ before NAC, as well as according to the type of axillary surgery performed. The study involved 291 patients: 131 were cN0 and 160 were cN+ converting to ycN0 after NAC. After a median monitor period of 43 months, axillary relapse was identified in three cN0 (2.3%) and two cN+ (1.3%) patients. No significant discrepancies were found in disease-free survival, distant disease-free survival, overall survival, or breast-cancer-specific survival between the groups or between SLNB-only and ALND procedures. When performed after NAC, SLNB appears to be a reliable option with favorable prognostic patterns and low axillary recurrence rates for both cN0 and cN+ patients.
UR  - https://galaxypub.co/article/from-cn-to-ycn0-sentinel-node-biopsy-as-a-safe-alternative-to-alnd-post-neo-adjuvant-chemotherapy-ivnkmfd5osmlyt6
ER  -