%0 Journal Article
%T Hibiscus sabdariffa Leaf Extract Enhances Molecular Gene Expression of Insulin and GLP-1 Receptors in Streptozotocin-Induced Rats
%A Basiru Olaitan Ajiboye
%A Courage Dele Famusiwa
%A Damilola Ifeoluwa Oyedare
%A Biola Paul Julius
%A Zainab Odunola Adewole
%A Oluwafemi Adeleke Ojo
%A Ajoke Fehintola Idayat Akindele
%A Hossein Hosseinzadeh
%A Bartholomew I.C. Brai
%A Babatunji Emmanuel Oyinloye
%A Sara Vitalini
%A Marcello Iriti
%J Specialty journal of Pharmacognosy, Phytochemistry, and Biotechnology
%@ 3062-441X
%D 2024
%V 4
%N 1
%R 10.51847/9lS5Ohuhiv
%P 59-73
%X This study investigated the therapeutic effects of flavonoid-rich Hibiscus sabdariffa L. leaf extracts in rats with streptozotocin-induced diabetes. The study evaluated various biochemical parameters, including markers of redox stress, inflammation, pancreatic tissue histology, insulin levels, purinergic enzyme functions, lipase activity, and homeostasis models for β-cell function and insulin resistance (HOMA-β, HOMA-IR). The results showed that H. sabdariffa extracts significantly (P < 0.05) alleviated redox imbalance and inflammation in the diabetic rats. This was evidenced by the reduction of malondialdehyde (MDA), interleukins (IL-1β, IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP), alongside an increase in antioxidant enzymes such as reduced glutathione (GSH), glutathione-S-transferase (GST), catalase (CAT), and glutathione peroxidase (GPx). Histological evaluation of pancreatic tissue demonstrated protection against the degeneration of both acinar and β-cells. In addition, there was a significant increase in insulin concentration and a decrease in lipase activity. The extracts also modulated purinergic enzymes, including ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) and ATPase, while improving both HOMA-β and HOMA-IR indices. Notably, the extracts activated the gene expression of insulin and GLP-1 receptors in the treated diabetic rats. These findings highlight the potential of H. sabdariffa leaf extracts as a natural therapeutic approach for diabetes management.
%U https://galaxypub.co/article/hibiscus-sabdariffa-leaf-extract-enhances-molecular-gene-expression-of-insulin-and-glp-1-receptors-i-ntaqdudnwd1svcp