%0 Journal Article
%T Impact of Chemical Structure and Hydrolysis Mechanisms on the Pharmacological Effects and Toxicity Profiles of Licensed Platinum-Based Drugs
%A Kim Ji-Hoon
%A Park Soo-Yun
%A Choi Min-Jae
%J Annals of Pharmacy Practice and Pharmacotherapy
%@ 3062-4436
%D 2023
%V 3
%N 1
%R 10.51847/SQSRbv0oT9
%P 103-113
%X Resistance and toxicity remain major challenges in platinum-based anticancer therapies. This study aims to compare how the chemical structure and hydrolysis mechanisms influence the pharmacological activity and toxicological profiles of approved platinum drugs: Cisplatin, Carboplatin, Oxaliplatin, Nedaplatin, Lobaplatin, Heptaplatin, and Satraplatin. Carboplatin and Nedaplatin undergo hydrolysis via a two-step hydration process, ultimately generating the same active species as Cisplatin, namely diaquadiamine-platinum. In contrast, Oxaliplatin, Lobaplatin, Heptaplatin, and Satraplatin share a hydrolysis mechanism in which the first step involves ring-opening and addition of a water molecule, followed by ligand loss and formation of the di-aquated product through a second water addition. Regarding toxicity, Cisplatin, Carboplatin, and Oxaliplatin exhibit nephrotoxic effects, while Cisplatin and Heptaplatin are particularly nephrotoxic. Myelosuppression represents the primary dose-limiting toxicity for Carboplatin, Oxaliplatin, Nedaplatin, Lobaplatin, and Satraplatin.
%U https://galaxypub.co/article/impact-of-chemical-structure-and-hydrolysis-mechanisms-on-the-pharmacological-effects-and-toxicity-p-ucrahl2hrc9a93p