TY  - JOUR
T1  - Impact of Chemical Structure and Hydrolysis Mechanisms on the Pharmacological Effects and Toxicity Profiles of Licensed Platinum-Based Drugs
A1  - Kim Ji-Hoon
A1  - Park Soo-Yun
A1  - Choi Min-Jae
JF  - Annals of Pharmacy Practice and Pharmacotherapy
JO  - Ann Pharm Pract Pharmacother
SN  - 3062-4436
Y1  - 2023
VL  - 3
IS  - 1
DO  - 10.51847/SQSRbv0oT9
SP  - 103
EP  - 113
N2  - Resistance and toxicity remain major challenges in platinum-based anticancer therapies. This study aims to compare how the chemical structure and hydrolysis mechanisms influence the pharmacological activity and toxicological profiles of approved platinum drugs: Cisplatin, Carboplatin, Oxaliplatin, Nedaplatin, Lobaplatin, Heptaplatin, and Satraplatin. Carboplatin and Nedaplatin undergo hydrolysis via a two-step hydration process, ultimately generating the same active species as Cisplatin, namely diaquadiamine-platinum. In contrast, Oxaliplatin, Lobaplatin, Heptaplatin, and Satraplatin share a hydrolysis mechanism in which the first step involves ring-opening and addition of a water molecule, followed by ligand loss and formation of the di-aquated product through a second water addition. Regarding toxicity, Cisplatin, Carboplatin, and Oxaliplatin exhibit nephrotoxic effects, while Cisplatin and Heptaplatin are particularly nephrotoxic. Myelosuppression represents the primary dose-limiting toxicity for Carboplatin, Oxaliplatin, Nedaplatin, Lobaplatin, and Satraplatin.
UR  - https://galaxypub.co/article/impact-of-chemical-structure-and-hydrolysis-mechanisms-on-the-pharmacological-effects-and-toxicity-p-ucrahl2hrc9a93p
ER  -