TY  - JOUR
T1  - Next-Generation Anti-Adhesive Medical Devices: Leveraging Plasma-Grown Nanostructured Silver for Biofilm Prevention
A1  - Henrique Silva
A1  - André Pinto
A1  - Vasco Neves
JF  - Interdisciplinary Research in Medical Sciences Specialty
JO  - Interdiscip Res Med Sci Spec
SN  - 3062-4401
Y1  - 2025
VL  - 5
IS  - 1
DO  - 10.51847/vTocMgfDlu
SP  - 42
EP  - 56
N2  - Biofilm accumulation on implantable silicone-based medical devices remains a critical challenge for healthcare systems. To address this, we introduce a novel, multi-modal strategy to preemptively inhibit bacterial colonization. This study investigates the efficacy of plasma-synthesized nanostructured metallic silver coatings—specifically three distinct geometries termed “Sharp blades,” “Thick blades,” and “Leaves”—immobilized onto stretchable substrates via a plasma-polymerized penta-fluorophenyl methacrylate thin film. Crucially, these coatings leverage a synergistic mechanism: the combination of inherent silver bacteriophobicity with the surface’s superhydrophobic topography creates a profound physical impediment to initial bacterial attachment. The bacteriophobic performance, which is tunable by controlling the plasma polymerization parameters of the underlying polymer, was rigorously characterized using FE-SEM, live/dead staining, and direct adhesion counts across various bacterial strains. The results demonstrate a remarkable reduction in bacterial adhesion by up to six orders of magnitude compared to bare surfaces, establishing this plasma-mediated nanostructuring as a highly effective, non-leaching methodology for engineering next-generation, biofilm-resistant medical materials.
UR  - https://galaxypub.co/article/next-generation-anti-adhesive-medical-devices-leveraging-plasma-grown-nanostructured-silver-for-bio-ubunnsiocfzypy8
ER  -