TY  - JOUR
T1  - Prolonged Corneal Analgesia Without Impairing Wound Healing Using a Novel Quaternary Ammonium N-Propylamiodarone Bromide
A1  - Isabella Rivera
A1  - Nathan Morales
A1  - Wyatt James
JF  - Pharmaceutical Sciences and Drug Design
JO  - Pharm Sci Drug Des
SN  - 3062-4428
Y1  - 2023
VL  - 3
IS  - 1
DO  - 10.51847/SyHW5XV0YB
SP  - 188
EP  - 197
N2  - Pain originating from corneal epithelial damage is a prevalent and distressing symptom caused by factors such as mechanical trauma, chemical exposure, ulceration, UV irradiation, or infection. Despite its frequency, effective and long-lasting treatments remain limited. This study evaluated a newly synthesized quaternary ammonium compound, N-propylamiodarone bromide (NPA), for its ability to provide prolonged corneal analgesia via selective entry through transient receptor potential vanilloid 1 (TRPV1) channels, while ensuring normal epithelial repair. Corneal injury was induced in 24 adult Wistar rats, which then received topical applications of saline, oxybuprocaine, or NPA (n = 8 per group). Pain responses were quantified using the von Frey filament assay. In a separate experiment, 32 rats with intact corneas were treated with oxybuprocaine, capsaicin (TRPV1 agonist), or NPA alone or in combination with capsaicin (n = 8 per group) to assess effects on mechanical sensitivity. Corneal epithelial recovery following injury and treatment was evaluated using fluorescence microscopy and hematoxylin–eosin staining in an additional 8 rats.

NPA produced markedly prolonged analgesia compared to oxybuprocaine in injured corneas (maximum effect duration: 215 ± 11 vs 25 ± 2 min, P < 0.001) without causing ocular irritation. In normal corneas, NPA did not affect baseline sensitivity; however, when co-administered with capsaicin, it induced significantly extended anesthesia relative to oxybuprocaine (165 ± 15 vs 31 ± 2 min, P < 0.001). Importantly, NPA treatment did not impede epithelial wound healing. The novel compound NPA provides durable corneal analgesia without interfering with tissue repair, representing a promising candidate for the management of pain associated with corneal injury.
UR  - https://galaxypub.co/article/prolonged-corneal-analgesia-without-impairing-wound-healing-using-a-novel-quaternary-ammonium-n-prop-d23jblycqb5tnew
ER  -