TY  - JOUR
T1  - Quality Evaluation of Sustained-Release Domperidone Formulations
A1  - Zeb-un-Nisa Zeb-un-Nisa
A1  - Syed Imran Ali
A1  - Saira Shahnaz
A1  - Tayyaba Mumtaz
A1  - Muhammad Mustafa Swaleh
JF  - Pharmaceutical Sciences and Drug Design
JO  - Pharm Sci Drug Des
Y1  - 2021
VL  - 1
IS  - 1
SP  - 32
EP  - 40
N2  - Using hydrophilic Methocel® K4M, the current study sought to design a sustained-releasing and acting formulation of Domperidone, an antiemetic medication used to treat nausea and vomiting, with a typical dosage that is administered twice or three times per day. The sustained-release formulation was made using various ratios of K4M, and its quality and stability were assessed. The optimized formulation was chosen for dissolution studies and similarity profiles after pre-compression and post-compression features were analyzed. Studies on drug dissolution showed that a tablet containing CF2 had the best release profile for once-daily use. The preparation of long-acting domperidone matrices was accompanied by the display of favorable characteristics necessary for the perfect once-daily formulation. The creation of a gel layer followed by gel erosion may be the mechanism, providing a lengthy, slow-releasing pattern and a desired therapeutic effect. The idea of controlled-release formulations benefits patients and carers by decreasing the frequency of doses and the likelihood of missing doses or an overnight interval between doses.
UR  - https://galaxypub.co/article/quality-evaluation-of-sustained-release-domperidone-formulations-af0hrxqwmae8wpc
ER  -