TY  - JOUR
T1  - The Alternative Splicing of CLSTN1 Driven by ESRP1 Suppresses Gastric Cancer Metastasis
A1  - Emily Fernandez
A1  - Mei Q. Moore
JF  - Asian Journal of Current Research in Clinical Cancer
JO  - Asian J Curr Res Clin Cancer
SN  - 3062-4444
Y1  - 2025
VL  - 5
IS  - 1
DO  - 10.51847/cZOZ2TW0T4
SP  - 177
EP  - 195
N2  - The spread of tumors significantly worsens outcomes for individuals with gastric cancer. RNA-binding proteins (RBPs) play key roles in cancer spread, although their specific contributions to gastric cancer remain underexplored. In this work, we identified ESRP1, an epithelial-specific RBP, as a critical modulator of metastatic behavior in gastric cancer cells. Levels of ESRP1 show an inverse association with both distant and lymph node metastases in affected patients. Experiments confirmed that ESRP1 suppresses cell migration and invasion in gastric cancer models both in laboratory settings and animal studies. At the molecular level, ESRP1 facilitates alternative splicing of exon 11 in CLSTN1 pre-mRNA. The resulting shorter isoform of CLSTN1 strengthens the interaction between E-cadherin and β-catenin, while enhancing ubiquitination and subsequent degradation of β-catenin protein, ultimately restraining migratory and invasive properties of gastric cancer cells. This investigation underscores ESRP1's suppressive influence on gastric cancer spread and uncovers additional mechanistic insights. Findings suggest that ESRP1 and CLSTN1 could serve as promising targets for interventions against metastatic gastric cancer.
UR  - https://galaxypub.co/article/the-alternative-splicing-of-clstn1-driven-by-esrp1-suppresses-gastric-cancer-metastasis-wqievcsbxv3f5cw
ER  -