TY  - JOUR
T1  - The Role of Age in Breast Cancer Subtypes: A Comparative Study in Young and Older Women
A1  - Hatice Özışık
A1  - Atike Pınar Erdoğan
A1  - Zeki Gökhan Sürmeli
A1  - Ferhat Ekinci
A1  - Raika Durusoy
A1  - Burçak Karaca
JF  - Asian journal of Current Research in Clinical Cancer
JO  - Asian J Curr Res Clin Cancer
Y1  - 2021
VL  - 1
IS  - 2
DO  - 10.51847/IeFF4VKdkc
SP  - 9
EP  - 14
N2  - Molecular pathological classification shows that triple-negative and human epidermal growth factor receptor 2 (HER-2) positive breast cancer subtypes are associated with a worse prognosis compared to luminal disease; therefore, the main aim was to evaluate the effect of age on the identification of molecular subtypes and whether the disparity in outcomes between patients aged ≤ 35 years and those aged > 35 years is due to the diversity of molecular subtypes. Women who are diagnosed with breast cancer at a young age (≤ 35 years) have significantly shorter overall survival durations. Trial participants included 216 patients ≤ 35 years and 212 patients > 35 years who were randomly selected from all breast cancer patients who visited the Department of Oncology, Ege University. Using immunohistochemistry, the molecular subtyping was based on the Ki-67 proliferation index, cerb-B2, progesterone receptors (ER, PR), and estrogen. Cerb-B2 (-), Ki-67 ≤ 15, ER (+), and PR (+) were considered indicators of luminal illness. Luminal B patients had ER/PR (+), cerb-B2 (-)/(+), and Ki-67 ≥ 15. The triple-negative disease was considered if all three receptors were negative, whereas HER-2-positive disease was defined by the presence of cerb-B2 and the absence of hormone receptors. 19% of the younger group were triple negative, and 52% of the younger group were Luminal B. The majority of the group > 35 years old was Luminal B (39%) as it is comparable to the very young population; however, Luminal A (31%) with good prognostic aspects came next. The two age groups did not differ statistically in molecular subtypes; however, the triple-negative subtype and Ki-67 ≥ 15%, which are associated with a worse prognosis, were numerically greater in the group aged ≤ 35 years. The prognosis of young women with breast cancer is worse. However, the molecular subtypes of the two different age groups did not differ significantly in our study. The limited size of the study cohort may account for this, but it may also indicate that age is a separate predictive factor from other clinicopathologic characteristics. However, given that the largest category in the very young population had Luminal B and triple negatives, this diversion may account for the poorer prognosis of the disease in this group.
UR  - https://galaxypub.co/article/the-role-of-age-in-breast-cancer-subtypes-a-comparative-study-in-young-and-older-women-tcd7ap12pqaimbr
ER  -