TY  - JOUR
T1  - Therapeutic Potential of Himatanthus drasticus Latex Proteins in Wound Healing: Modulation of Inflammatory and Proliferative Phases
A1  - Petar Marković
A1  - Nikola Jovanović
A1  - Stefan Ilić
JF  - Interdisciplinary Research in Medical Sciences Specialty
JO  - Interdiscip Res Med Sci Spec
SN  - 3062-4401
Y1  - 2023
VL  - 3
IS  - 2
DO  - 10.51847/4CoXRtjbLv
SP  - 172
EP  - 185
N2  - This study explored the wound-repair effects of proteins isolated from the latex of Himatanthus drasticus (HdLP) using a murine excisional wound model. Toxicity tests revealed that HdLP, at concentrations between 12.5 and 100 μg/ml, was safe for fibroblast cells, and dermal irritation assays confirmed it did not provoke adverse skin reactions. Wounds were treated with HdLP at 0.5%, 1.0%, and 2.0%, or with a vehicle control, and healing was assessed through gross observation, histology, and analysis of inflammatory markers. Treatment with HdLP triggered an early increase in IL-1β during the inflammatory phase, which appeared to support a timely rise in IL-10 during the proliferative phase. Enhanced fibroblast proliferation, deposition of new collagen fibers, and orderly re-epithelialization contributed to faster and more complete wound closure. These findings provide the first evidence that latex-derived proteins from Himatanthus drasticus actively participate in tissue remodeling and wound healing.
UR  - https://galaxypub.co/article/therapeutic-potential-of-himatanthus-drasticus-latex-proteins-in-wound-healing-modulation-of-inflam-pqlfie1nwefauql
ER  -