Early enamel caries lesions usually appear as white, opaque spots with a softer texture than the surrounding healthy enamel and become more prominent when dry. This study aims to investigate the effectiveness of Cervitec® Plus and Fluor Protector® varnishes in minimizing the occurrence of white spot lesions in orthodontic patients. A prospective controlled trial was conducted, including 30 participants in a split-mouth study design. Cervitec® Plus varnish was used in the first quadrant, while Fluor Protector® varnish was used in the second quadrant. Enamel fluorescence values were recorded using a Diagnodent pen at three intervals: T0 (pre-bonding), T1 (one month after strap-up), and T2 (two months after strap-up). A t-test showed a significant decrease in enamel fluorescence values between T0 and T2, as well as between T1 and T2, in both varnish groups. However, a Mann-Whitney test comparing the two groups found no statistically significant difference in effectiveness between Cervitec® Plus and Fluor Protector®. The findings suggest that both varnishes are equally effective in reducing white spot lesions during orthodontic treatment. Therefore, their use is recommended in the prevention and management of white spot lesions in orthodontic patients.
