Composition and Potential Applications of Biologically Active Complexes from Natural Raw Materials

This research explores a novel approach to enhance the absorption of biologically active compounds with poor bioavailability by combining partially soluble arabinogalactan polysaccharides with chitosan-based polysaccharides. The study focuses on a bioactive polymer matrix composed of chitosan succinate, succinic anhydride, and arabinogalactan with covalently unbound dihydroquercetin, with respective weight proportions of 3.0-5.0, 2.0-4.0, 15.0-20.0, and 3.0-5.0. These elements act as specialized carriers, ensuring the precise transport of therapeutic and diagnostic agents—including nucleic acids, enzymes, hormones, and vitamins—to hepatocytes (parenchymal liver cells). Experimental findings highlight the significant membranotropic potential of arabinogalactan sourced from Siberian larch (Larix sibirica). Arabinogalactan facilitates improved intestinal absorption of bioactive molecules with limited natural uptake by forming a stable complex with pharmaceutical compounds and interacting with the asialoglycoprotein receptor. This study also investigates the effect of arabinogalactan on the quality and processing characteristics of PSE-like broiler meat. When incorporated at 0.5% of the total sausage formulation, it increased moisture retention by 5% and reduced thermal processing losses by 6%. Furthermore, the improvement of peroxide and acid values during storage indicates an inhibitory effect on oxidative degradation, which effectively increases product stability and prevents spoilage. In addition, consideration is given to the development of an advanced gel-like polymer complex derived from a polysaccharide matrix, with potential applications in health-supporting technologies.