The cause of the severe acute respiratory syndrome during the current pandemic was COVID-19 (SARS-CoV-2), which led to thousands of cases and significant death rates in all affected countries. The immune-therapy methods for COVID-19 treatment are the main topic of this review. Administration of interferon, convalescent plasma, intravenous immunoglobulin, monoclonal antibodies, cellular therapies, and immunomodulatory medications are the unique immunotherapeutic approaches. Immunotherapy is recommended in addition to antivirals since the infected patient has immunity against the antigen, and the virus inhibits the activation of interferon to prevent the immune system from attacking it. Interferons are used to treat the infection at specific stages. Worldwide, patients with severe COVID-19 infections are treated with convalescent plasma therapy. Several antibodies neutralise the virus and combat SARS-CoV-2 at various phases of its life cycle. To manage the cytokine storms caused by COVID-19 in its late stages, the immune response is modulated with JAK inhibitors, corticosteroids, and other medications. To combat the virus, patients need to receive freshly updated medication due to changes in the cytokine storm and antibody reactivity against SARS-CoV-2. Investigating the process of development, the immune system’s reaction to infection, and viral-mediated reactions aids in the creation of effective therapeutic and preventive drugs.
