The inappropriate storage and disposal of unused medicines in homes have sparked worldwide concerns owing to their adverse effects on the environment, human health, and animal well-being. This research seeks to examine practices related to medication storage and disposal in southern Jordan, identify socio-demographic factors associated with the household accumulation of medicines, and assess public knowledge about proper medicine disposal. A cross-sectional study was carried out in southern Jordan from January to July 2023. An online questionnaire was developed based on an extensive review of existing literature. Data were analysed using the Statistical Package for the Social Sciences (SPSS). Chi-square tests and logistic regression were utilised to explore associations between socio-demographic variables and medication storage behaviours. Every participant reported keeping unused medications at home, with 43.4% being expired. The main reason for retention, reported by 49.8% of respondents, was expected future need. Analgesics represented the most frequently stored category and were commonly placed in kitchens and bathrooms. Logistic regression showed significant associations between storage practices and factors including age over 61 years (p-value <0.001), illiteracy (p-value = 0.006), large family size (p-value = 0.012), absence of health insurance (p-value <0.001), and high income (p-value = 0.027), whereas gender showed no significant influence. Half of the participants disposed of medications by throwing them in the garbage. Pharmacists served as the main source of information on disposal, but knowledge about the risks of improper disposal remained inadequate. Rates of unused medication storage and improper disposal were elevated in southern Jordan. The findings highlight the need for governmental regulations on medicine dispensing to limit quantities supplied and minimise excess household accumulation. Additionally, educational campaigns are required to inform the public about safe disposal options for unused medicines at home and to help reduce related hazards.
