A considerable number of patients undergoing haemodialysis (HD) do not follow their prescribed medication schedules, resulting in adverse health consequences and reduced survival probabilities. This underscores the importance of developing strategies to enhance medication compliance and consequently improve patient outcomes. To assess the effectiveness of motivational interviewing as an advanced counselling technique in enhancing medication adherence in HD patients. A prospective pre-post design study was carried out involving 63 HD patients across multiple dialysis centres. Participants underwent three motivational interviewing (MI) sessions aimed at exploring their perceptions regarding medications and tackling obstacles to adherence. Medication adherence was measured using the General Medication Adherence Scale (GMAS). The effect of MI on adherence improvement was examined with an independent t-test, setting the significance level at 0.05. The study enrolled 63 patients (27 men and 36 women; average age 48.5 ± 13.9 years). The average duration on dialysis was 7.7 ± 6.0 years, and the mean number of prescribed medications was 8.1 ± 2.2. Results from the paired t-test indicated a notable rise in adherence scores from baseline in the domains related to patient attitudes toward non-adherence and the burden of additional illnesses combined with pill load by the study's conclusion (p < 0.05). In contrast, the domain concerning financial barriers showed no significant change (p = 0.507). MI proved successful in fostering a more positive internal mindset by addressing patients' conflicting feelings, thereby promoting better medication compliance. The findings demonstrate that pharmacist-delivered motivational interviewing significantly enhances medication adherence in HD patients. It is recommended that healthcare providers adopt this approach to better support HD patients in managing their medication regimens.
