Insights into Omeprazole Release from Solid Dosage Forms via Thermal and Kinetic Analysis

The central aim pursued in this work was to investigate and assess the capacity of designated excipients to yield efficacious sustained-release omeprazole platforms. Toward this end, six distinct excipients were chosen (lactose monohydrate, medium-viscosity alginic acid, Avicel® PH-101, Avicel® PH-102, PVP K-30, and magnesium stearate). Selection was guided by criteria grounded in the physicochemical attributes of these materials (e.g., minimal toxicity) and their economic accessibility. Two excipient combinations were employed for tablet preparation, applying distinct methodologies characterized by practicality, modest expense (straightforward blending, compaction, and wet granulation), and limited time demands. The experimental outcomes revealed that the fabricated systems responded favorably, both in terms of tablet properties (hardness, dimensions, compositional uniformity) and in their ability to liberate omeprazole in a delayed fashion post-administration. Notably, one formulation (F7) exhibited a release pace comparable to that of the marketed product omeprazole Losec® (80% liberated within a two-hour window), whereas formulation F3 demonstrated a slower yet relatively consistent release extending over a longer span (no less than four hours) and may therefore be regarded as a promising foundation for the development of prolonged, stable-release delivery constructs (e.g., 24 h release) for pharmaceutical agents. The remaining preparations displayed analogous, intermediate-duration release profiles. Every release curve was additionally interpreted through the lens of interactions between excipients themselves and/or between excipients and OME, as probed via thermal analysis methodologies. In summation, the systems explored herein are characterized by comparatively low production costs, elevated performance, and a range of omeprazole release rates. Accordingly, they can be considered promising for future application with other active compounds, subject to suitable adjustments.