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Annals of Pharmacy Practice and Pharmacotherapy

2022 Volume 2
Creative Commons License

Investigation of Butaselmevit’s Acute and Chronic Toxicity in Laboratory Animals


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  1. Laboratory of Immunology, Institute of Animal Biology, National Academy of Sciences of Ukraine, Lviv, Ukraine.
  2. Department of Hygiene, Sanitation and General Veterinary Prevention, Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine.
  3. Laboratory of Pharmacology and Toxicology, State Research and Control Institute for Veterinary Medicines and feed additives, Lviv, Ukraine.
  4. Department of Clinical Pharmacy, Pharmacotherapy, Pharmacognosy and Pharmaceutical Chemistry, Zaporizhzhya State Medical University, Zaporizhzhya, Ukraine.
  5. Department of Pharmacy Management and Economics, and Pharmaceutical Technology, Zaporizhzhya State Medical University, Zaporizhzhya, Ukraine.
  6. Department of Natural Sciences for Foreign Students and Toxicological Chemistry, Zaporizhzhya State Medical University, Zaporizhzhya, Ukraine.
  7. Department of Social Medicine, Public Health, Medical and Pharmaceutical Jurisprudence, Zaporizhzhya State Medical University, Zaporizhzhya, Ukraine.
  8. Department of Pharmacy Management and Economics, Zaporizhzhya State Medical University, Zaporizhzhya, Ukraine.
Abstract

This study aimed to investigate the hepatoprotective effects of potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate’s on tetracycline and viral hepatitis models in chickens. The intact Cobb 500 cross-broiler chickens were subjected to a biochemical analysis of their blood and liver serum. According to the specified specifications, each group of chickens was housed independently in a distinct cell in the same room with the same climatic characteristics. It was found that “Butaselmevit” had a dose-dependent effect on laboratory animals’ leukopoiesis, hematological profile, and function of the liver. Research on the model of tetracycline-induced hepatitis in chickens showed that the compound 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate has a hepatoprotective effect that is comparable to that of the reference medication, Thiotriazolin®. According to the results of a biochemical study, in the model of infectious hepatitis, potassium 2-((4-amino-5- (morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio) acetate is combined with the traditional antibiotic Enrofloxacin® to produce hepatoprotective effects.


How to cite this article
Vancouver
Martyshuk T, Gutyj B, Vyshchur O, Paterega I, Kushnir V, Bigdan O, et al. Investigation of Butaselmevit’s Acute and Chronic Toxicity in Laboratory Animals. Ann Pharm Pract Pharmacother. 2022;2:32-8. https://doi.org/10.51847/kMDaMfkr0C
APA
Martyshuk, T., Gutyj, B., Vyshchur, O., Paterega, I., Kushnir, V., Bigdan, O., Bushueva, I., Parchenko, V., Mykhailiuk, E., Aleksieiev, O., et al. (2022). Investigation of Butaselmevit’s Acute and Chronic Toxicity in Laboratory Animals. Annals of Pharmacy Practice and Pharmacotherapy, 2, 32-38. https://doi.org/10.51847/kMDaMfkr0C

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