Coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus and represents a significant global health challenge. Although several therapeutic agents have shown promise for prevention or treatment, no specific drug has been definitively developed for COVID-19. Recently, natural products have emerged as potential candidates for COVID-19 management. This study investigated the potential effects of Coriandrum sativum L. (CSL) against COVID-19 using a network pharmacology approach. Active compounds from CSL were identified through database searches, followed by analysis of protein–protein interactions relevant to COVID-19. Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were conducted to elucidate the possible mechanisms of action. Network pharmacology analysis revealed 51 potential targets, with EGFR, AR, JAK2, PARP1, and CTSB identified as key hub targets. GO and KEGG analyses suggested that CSL may exert protective effects against COVID-19 by modulating multiple critical biological pathways. Overall, these results indicate that CSL could potentially contribute to the prevention and inhibition of various processes involved in COVID-19 pathogenesis.
