The implementation of telepharmacy offers new opportunities for healthcare delivery and helps address the challenge of limited pharmacist availability. This study aimed to assess attitudes toward providing and utilizing telepharmacy services in Bulgaria. A total of 379 participants, predominantly healthcare professionals, took part, with an average age of 44.38 ± 12.39 years. Data were analyzed using IBM SPSS Statistics v.23. Over 90% of respondents reported using the Internet to search for health-related information, and many indicated that they read medication package leaflets before use. Most participants expressed skepticism toward dietary supplements purchased online. More than 56% stated they would not purchase prescription medications online or via a mobile app, even if legally permitted. A smaller portion indicated willingness to consult a pharmacist for remotely prescribed therapy or to use a mobile app to track their medication regimen. The expansion and acceptance of telepharmacy represent a complex challenge requiring collaboration among public and private sectors, as well as scientific and academic institutions, to achieve effective outcomes and enhance healthcare services.