This follow-up investigation examined the sustained effects of pillbox utilization on medication adherence among individuals with type 2 diabetes mellitus (T2DM) across a two-year period. A cross-sectional analysis involving 52 participants was separated into two cohorts: the pillbox (intervention) group and the non-pillbox (control) group. Adherence was evaluated via the pill count technique, while clinical parameters including blood glucose concentrations were documented. The findings indicated that the pillbox group maintained markedly superior adherence rates throughout the duration, rising from 94.01% at baseline to 96.67% at the two-year mark. By comparison, adherence in the non-pillbox group decreased from 88.62% to 88.26%. Postprandial blood glucose management showed significant improvement in the pillbox group (141.38 mg/dl to 129.88 mg/dl), whereas the non-pillbox group exhibited a rise (137.96 mg/dl to 145.69 mg/dl). No statistically significant alterations were observed in fasting or random blood glucose values. The analysis highlighted education and occupation as key determinants of adherence, while variables such as age, gender, comorbidities, and adjustments to medication demonstrated limited or insignificant influence. The results imply that pillbox-based interventions can successfully enhance prolonged medication adherence and postprandial blood glucose regulation in patients with T2DM, especially when accounting for sociodemographic variables like education and occupation. Additional studies are recommended to investigate the wider applications of these outcomes for diabetes care and possible approaches to boost adherence across varied patient groups.
