Hypertension, a major silent threat to human health, is marked by persistently elevated blood pressure. Although conventional pharmacological treatments have shown effectiveness, they are often limited by high costs and adverse effects. Recently, natural products have emerged as potential alternatives for managing hypertension. This study explored the antihypertensive potential of Allium schoenoprasum using network pharmacology and molecular docking approaches. Bioactive compounds and relevant targets were identified through comprehensive database searches. Protein-protein interaction (PPI), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to elucidate the key targets of Allium schoenoprasum. A total of 10 bioactive compounds were identified, and PPI analysis highlighted SCR, STAT3, PIK3R1, CTNBB1, and ESR1 as central targets in hypertension. Functional enrichment via GO and KEGG indicated that these targets are predominantly associated with protein binding and catalytic activities within the membrane and cytoplasm. Molecular docking further revealed that kaempferol, isorhamnetin, and quercetin are the most active compounds against hypertension. Overall, Allium schoenoprasum demonstrates promising antihypertensive effects through the combined application of network pharmacology and molecular docking strategies.
