Prostate cancer remains the leading cause of cancer-related deaths among men globally. In 2020, Mexico’s National Institute of Statistics and Geography reported a mortality rate of 10.89 per 10,000 men aged 60 years and older due to this condition. The purpose of this study was to analyze prostate cancer-related statistical data specific to the southern region of Mexico. Mortality records from 23,527 male patients diagnosed with prostate cancer between 1979 and 2020 were reviewed using sources such as GLOBOCAN 2020, the Mexican Ministry of Health’s Information System, Google Scholar, and PubMed. The findings showed that Veracruz reported the highest mortality rate in 2018, exceeding the numbers from Campeche (219), Chiapas (977), Guerrero (724), Oaxaca (1356), Quintana Roo (623), and Yucatán (603). The analysis highlights aging as a major contributing factor to prostate cancer risk and suggests that population growth in different Mexican cities may also influence these trends.