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Choosing an appropriate biomaterial is crucial when designing scaffolds intended for biomedical use. In particular, creating nanofibrous architectures by electrospinning requires careful selection of the polymer. Poly (2-ethyl-2-oxazoline) (PEOX) is one such candidate polymer suitable for electrospinning and can be utilized to fabricate scaffolds for medical purposes. PEOX dissolves readily in water, which is a significant advantage for biological systems, and it also exhibits solubility in various organic solvent mixtures. Based on this, the present work provides an initial evaluation of PEOX for scaffold fabrication through electrospinning and investigates its feasibility for future applications in tissue-engineering-related research. PEOX scaffolds were produced using both aqueous and organic solvent systems, and the influence of solvent type on morphology and physical behavior was assessed. Scanning Electron Microscopy revealed that fibres generated from an aqueous PEOX solution formed a consistent nanofibrous network, while those prepared with organic solvents resulted in micro-scale fibres. Wettability, determined using contact angle analysis, indicated higher hydrophilicity for PEOX (aq.) with a contact angle of 55.2°, compared with 70.38° for PEOX (org.). Mechanical characterization through Young’s modulus demonstrated that PEOX (org.) achieved a tensile strength of 1.9 MPa, whereas PEOX (aq.) displayed 1.02 MPa. These observations demonstrate that solvent choice significantly impacts the electrospinning behavior of PEOX and the resulting scaffold characteristics. Overall, the fabricated PEOX scaffolds show promising features suitable for biomedical fields such as tissue engineering.
