The likelihood of chronic illnesses and concurrent usage of several pharmaceuticals has grown due to the aging population and longer life expectancy, which might result in negative drug interactions and responses. This review research was conducted to look into the elderly’s polypharmacy management strategies, as there is no comprehensive study on the subject. Polypharmacy, the elderly, and prevalence were searched in the PubMed, Science Direct, Scopus, Google Scholar, Ovid, Magiran, and Sid databases between 2005 and 2023 to perform this review research. The data showed that the age categories of 70–74 years and 80–84 years had the highest frequency of polypharmacy, and that polypharmacy was associated with both the individual’s demographics and health state, as well as the features of the health facility. In addition, research has shown that there is a relationship between the pattern of polypharmacy consumption and the source of knowledge regarding medications. Several studies have emphasized the need for ongoing monitoring of medications taken by the elderly to prevent pharmacological adverse effects. The findings of this study showed that with the application of tactics such as doctor-pharmacist communication, teaching the elderly about the risks of self-harming while taking medications, and educating the elderly about the restrictions of utilizing herbal remedies. It is possible to significantly minimize the variety of drug regimens among the elderly and make drug usage in this age group simpler by utilizing electronic instruments to track medication intake and by following protocols and criteria when administering medications.
