Written by İrfan Çelik
Published on Vol 1 Issue 2, 2021
Globally, epidemiological studies have shown a higher risk of malignant melanoma. To properly counsel their patients, dental students must be well-versed in the latest facts on malignant melanoma. This study aimed to assess the understanding and awareness of third, fourth, and fifth-grade students about malignant melanoma. A questionnaire with 11 questions was administered to 229 students (93 in the third grade, 64 in the fourth grade, and 72 in the fifth grade) who were enrolled in Marmara Univ
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Written by Hatice Özışık
Published on Vol 1 Issue 2, 2021
Molecular pathological classification shows that triple-negative and human epidermal growth factor receptor 2 (HER-2) positive breast cancer subtypes are associated with a worse prognosis compared to luminal disease; therefore, the main aim was to evaluate the effect of age on the identification of molecular subtypes and whether the disparity in outcomes between patients aged ≤ 35 years and those aged > 35 years is due to the diversity of molecular subtypes. Women who are diagnosed with breast c
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Written by Roop Preet Kaur
Published on Vol 1 Issue 2, 2021
Globally, gastric cancer ranks seventh in terms of incidence. A proto-oncogene that plays an important role in the pathophysiology of several human malignancies, such as gastric cancer, is HER2/neu. The introduction of trastuzumab has improved overall survival for gastric cancer that is HER2/neu-positive, locally advanced, and metastatic. To investigate the expression of HER2/neu in various histological types of stomach cancers and to establish the relationship between it and clinicopathological
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Written by H. Jansen
Published on Vol 1 Issue 2, 2021
Gastric cancer occurring at a younger age, referred to as early-onset gastric cancer (EOGC), represents 2–8% of all cases. This study aimed to define and describe this younger patient population using registry data. Patient records from the German Cancer Registry Group of the Society of German Tumor Centers—Network for Care, Quality and Research in Oncology (ADT) between 2000 and 2016 were examined. Age percentiles were used to stratify histological subtypes of gastric adenocarcinoma, allowing p
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Written by N. Abdel-Rahman
Published on Vol 1 Issue 2, 2021
Current ovarian cancer (OC) treatment follows the “Three-Pillar-Model,” which includes surgery, chemotherapy, and maintenance therapy. This study presents the first comprehensive analysis of a federal cancer registry for OC patients from Berlin and Brandenburg in Germany. The main aim was to assess established quality indicators, including surgical outcomes, use of adjuvant chemotherapy, and completeness of surgical staging in early-stage disease. Data from the Clinical Cancer Registry of Brande
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Written by H. Al-Farsi
Published on Vol 1 Issue 2, 2021
Quantitative Ultrasound (QUS) represents an emerging non-invasive imaging approach designed to monitor treatment responses. Research has demonstrated a strong association between QUS backscatter metrics and microscopic structural changes, as variations in ultrasound backscatter parameters significantly reflect increased cell death. Specifically, indicators related to scatterer size and concentration tend to rise with cellular degeneration. Numerous preclinical and clinical investigations have ex
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Written by L. Garcia
Published on Vol 1 Issue 2, 2021
Sporadic medullary thyroid carcinoma (MTC) is a rare cancer with widely varying clinical outcomes, and the influence of age at diagnosis on prognosis remains unclear. We examined 432 patients with sporadic MTC, followed for a median of 7.4 years, and stratified them into two age-based groups: under 65 years (group A, n = 338, 78.2%) and 65 years or older (group B, n = 94, 21.8%). No notable differences in baseline characteristics were observed between the groups, though younger patients had a si
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Written by L. Müller
Published on Vol 1 Issue 2, 2021
Hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer represents the most prevalent subtype, with endocrine therapy (ET) serving as the primary treatment approach. While anti-estrogen therapies are initially effective in most patients, around 50% of HR+ cases eventually develop resistance to ET, resulting in disease recurrence and limited long-term benefit. The introduction of cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors—palbociclib, riboci
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Written by R. Sharma
Published on Vol 1 Issue 2, 2021
Children with recurrent medulloblastoma face a dismal prognosis, prompting this study to investigate factors that may predict survival after relapse. We retrospectively examined clinical and biological data collected at initial diagnosis, along with key characteristics observed at relapse, for pediatric patients diagnosed with medulloblastoma between 2007 and 2017 at Gustave Roussy and Necker Hospital. Among 155 patients, 48 (31%) experienced a relapse over a median follow-up of 6.6 years (range
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