Volume 4 (2024)

Over the past decade, significant changes have occurred in the approach to drug impurity profiling, as reflected in pharmacopeial and regulatory standards. This review provides an in-depth exploration of impurity profiling, focusing on the regulatory requirements. It offers detailed insights into various impurities such as residual solvents, water impurities, elemental contaminants, and carcinogenic substances, with special attention to genotoxic impurities. To meet the required quality standard

---

Read More

The chemical entities quinazolinone and piperazine are highly valued in organic chemistry due to their broad spectrum of therapeutic and biological activities. To explore their potential applications, researchers developed a novel set of compounds combining quinazolinone and piperazine structures. These compounds, featuring the N-(4-oxo-2-(4-(4-(4-(2-(substituted phenylamino) acetyl) piperazin-1-yl) phenyl) quinazolin-3(4H)-yl) benzamide framework, were synthesized in high yields. Characterizati

---

Read More

Controlled-release drug delivery systems regulate the plasma drug concentrations through predefined release patterns over a specified period. The release rate directly affects drug absorption and systemic levels. These formulations help in reducing the frequency of daily dosing. This review examines the essential criteria, advantages, characteristics, and strategies for the development of controlled-release formulations to enhance drug delivery. These systems ensure the administration of the dru

---

Read More

This research focuses on the development and validation of cyclophosphamide-loaded microspheres for drug delivery. Cyclophosphamide, which is widely used in cancer therapy and immunosuppression, was analyzed using a newly established method with water as a diluent. The maximum absorption wavelength (λmax) was identified at 263 nm. Various analytical parameters, including linearity, precision, accuracy, limits of detection, robustness, and ruggedness, were assessed. The drug showed linearity over

---

Read More

Repurposing existing drugs for new therapeutic applications offers significant advantages over conventional drug development. Since these drugs have already passed safety evaluations, their failure rate is significantly reduced. In addition, leveraging pre-existing clinical data and established manufacturing methods accelerates the development process and reduces costs. While bringing a new drug to market typically requires 10-17 years and $2-3 billion, repurposed drugs can become available in 3

---

Read More