Written by David Johane Machate
Published on Vol 2 , 2022
Fresh coconut oil is known for its potential health benefits, particularly on hematological and biochemical markers, which may be attributed to its medium-chain triglycerides content. This prompted a closer examination of its effects in managing prothrombotic tendencies. This study aimed to investigate the effect of fresh coconut oil on the gastrointestinal tract microbiota, as well as hematological and biochemical markers, in Wistar rats. A total of ten adult Wistar rats, each weighing between
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Written by Walaa Najm Abood
Published on Vol 2 , 2022
Prostate cancer (PCa) is the most common type of cancer among men in developed countries. Despite the progress made in treatments such as surgery, radiation, and hormonal therapies, advanced-stage PCa still lacks effective management strategies. In response, alternative approaches, including dietary cancer-preventive agents, have gained attention, and medicinal plants are considered potential therapeutic options. Capparis cartilaginea (C. cartilaginea) contains various active compounds such as t
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Written by Romuald Dieudonne Noah Zibi
Published on Vol 2 , 2022
The growing resistance of Plasmodium parasites to current antimalarial drugs emphasizes the urgent need to discover alternative therapies. Medicinal plants historically used in the treatment of malaria are promising sources for new bioactive compounds, though their effectiveness requires scientific validation. This study aimed to evaluate the antiplasmodial and cytotoxic properties of alkaloid extracts from Coffea arabica and Coffea canephora. Alkaloids were extracted from powdered dry leaves of
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Written by Valery Sergun
Published on Vol 2 , 2022
Historically, minerals and plants have been used to treat dysmenorrhea symptoms, alleviate pain, replenish nutrients, and enhance overall well-being. In this study, we tested a novel plant-based dietary supplement consisting of cranberry extract, burdock root, both underground and above-ground parts of marsh cinquefoil, and natural mineral salt from Siberian lakes. The participants, all pubescent girls, did not have any diagnosed health issues or previous allergic reactions. Cardiovascular asses
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Written by Himashree Bora
Published on Vol 2 , 2022
In the current study, an evaluation was conducted on the extract of Coptis teeta Walls to determine its phytochemical content, phenolic and flavonoid levels, antioxidant capacity, and antibacterial effects against human pathogenic bacteria. The qualitative analysis revealed the presence of various bioactive compounds, including alkaloids, carbohydrates, saponins, phenols, flavonoids, tannins, terpenoids, cardiac glycosides, coumarin, starch, quinones, phlobatannins, and steroids. Among the extra
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Written by Ramesh Subramani
Published on Vol 2 , 2022
Infectious diseases remain the leading cause of death worldwide, with approximately 10 billion fatalities, accounting for 25% of all major deaths annually. This is largely attributed to the increasing number of infections in hospitals, particularly among patients who are vulnerable due to pre-existing conditions or injuries. Recently, there has been a significant increase in the prevalence of multidrug-resistant bacteria, which are responsible for severe healthcare-associated infections in hospi
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The Viscum genus includes a variety of species found in regions such as Europe, Africa, Asia, the Americas, and Australia. Mistletoe extracts and their formulations are widely used in alternative and complementary medicine for treating a wide range of ailments. This review focuses on studies that examine the phytochemical properties of mistletoe, which vary depending on the host tree and highlights research on its therapeutic effects. Mistletoe contains an array of bioactive compounds, including
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Written by Novita Sari Harahap
Published on Vol 2 , 2022
Regular moderate-intensity exercise can increase the effectiveness of the body’s endogenous antioxidants, and potentially boost immune defenses against viral infections. The bioflavonoids in lemon peel essential oil, known for their antioxidant properties, also help protect against free radical damage while acting as immunomodulators. This study aimed to evaluate the potential benefits of consistent moderate exercise and lemon peel essential oil on the immune response during the COVID-19 pandemi
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Written by Erik Johansson
Published on Vol 2 , 2022
There is a scarcity of data regarding determinants of warfarin dose requirements among Saudi patients, an ethnic group largely underrepresented in pharmacogenetic studies of warfarin. This study aimed to evaluate the prevalence of CYP2C9*2 and *3, CYP4F2 (G1347A), and VKORC1 –1639G>A genotypes and their influence on warfarin dose requirements in a cohort of Saudi individuals undergoing anticoagulation therapy. A total of 193 patients receiving long-term warfarin therapy with stable anticoagulati
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Written by Karim Mostafa
Published on Vol 2 , 2022
Aspirin remains a key treatment for acute ischemic stroke (AIS), though patient responses can vary widely. This study sought to develop a pharmacogenetic polygenic response score (PgxRS) capable of predicting adverse clinical outcomes in AIS patients receiving aspirin therapy. A retrospective cohort of 828 AIS patients treated with aspirin was analyzed. Fifteen candidate single nucleotide polymorphisms (SNPs) within genes influencing aspirin’s pharmacodynamics, transport, metabolism, and platele
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Written by Petra Novakova
Published on Vol 2 , 2022
Variants in pharmacogenes can profoundly influence drug responses, but data on their occurrence in Middle Eastern populations, particularly Saudis, are scarce. This study investigated the inheritance patterns of selected pharmacogenetic markers in healthy individuals from Saudi Arabia. A total of 95 unrelated healthy Saudi participants provided DNA samples, which were genotyped using the Affymetrix Axiom Precision Medicine Diversity Array. Thirty-eight variants in 15 pharmacogenes were chosen fo
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Written by Tran Minh Duc
Published on Vol 2 , 2022
Genetic variations in CYP2C9 and VKORC1 can significantly influence the safety and effectiveness of certain medications. Individuals carrying the CYP2C92 (rs1799853), CYP2C93 (rs1057910), or VKORC1 c.-1639G>A (rs9923231) alleles are at higher risk of adverse effects, particularly bleeding complications. Allele frequencies for CYP2C92, CYP2C93, and VKORC1 c.-1639G>A were sourced from Phase III of the 1000 Genomes Project, adhering to Fort Lauderdale data-sharing principles. Risk phenotypes were d
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Written by Anil Deshpande
Published on Vol 2 , 2022
Acute myeloid leukemia (AML) is a major form of cancer in children, yet treatment strategies remain limited and outcomes suboptimal. This study explored how Astragalus polysaccharide (APS) might influence immune cell dynamics and prognostic markers in pediatric AML. Gene expression data from the GEO dataset GSE2191 were analyzed to identify differentially expressed genes (DEGs), while APS-associated genes (APSRGs) were retrieved from the Swiss Target Prediction platform. Overlapping DEGs and APS
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Pharmacogenomics enables the prediction of individual drug responses based on genetic profiles, representing a critical step toward personalized medicine through routine genetic testing. Advances in high-throughput sequencing technologies have facilitated the simultaneous identification and interpretation of variants across multiple pharmacogenes. However, incorporating pharmacogenomics into clinical practice remains challenging, partly due to limited knowledge of population-specific pharmacogen
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Written by Martin Hofmann
Published on Vol 2 , 2022
Despite its widespread use for cardiovascular risk management, rosuvastatin’s long-term effectiveness is often limited by treatment cessation. Genetic differences, particularly in ABCG2 and SLCO1B1, can alter drug transport, efficacy, and side-effect profiles. The ABCG2 rs2231142 variant increases drug exposure, which may enhance lipid-lowering effects but also raises the likelihood of adverse events, especially muscle-related complications. Investigating these genetic influences in a real-world
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Written by Mohammad Rezaei
Published on Vol 2 , 2022
This paper explores emerging areas of pharmacogenomics that are becoming increasingly relevant to contemporary oncology pharmacy practice. The literature examined for this review was primarily drawn from recently approved therapeutics issued by the U.S. Food and Drug Administration and from newly incorporated treatment protocols within the National Comprehensive Cancer Network. The discussion highlights major pharmacogenomic themes, such as genomic variations that shape drug biotransformation, i
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Written by Lucas Ferreira
Published on Vol 2 , 2022
Although metabolic reprogramming is a defining feature of cancer, the ways in which metabolites mediate communication between cells remain largely unexplored. To bridge this knowledge gap, we investigated metabolite-driven intercellular interactions using single-cell RNA sequencing (scRNA-seq) data to delineate the metabolic architecture of the tumor microenvironment (TME) in lung adenocarcinoma (LUAD) and uncover novel metabolite signaling pathways. Dimensionality reduction of the scRNA-seq dat
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Dopamine replacement therapy forms the cornerstone of Parkinson’s disease (PD) management; however, patient responses, drug tolerability, and safety outcomes vary widely, largely due to genetic variations affecting drug metabolism and action. Despite this, the potential of multigenetic pharmacogenomics-guided therapy (MPGT) to optimize treatment in PD has been insufficiently explored. This prospective cohort study aimed to investigate whether MPGT could improve motor function in PD patients. We
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