Pharmacovigilance plays a crucial role in safeguarding patients by monitoring and managing adverse drug reactions (ADRs). This study explored the awareness, perceptions, and practical engagement of healthcare providers (HCPs) with pharmacovigilance and ADR reporting in Nineveh’s general hospitals. A cross-sectional survey was administered to HCPs in Mosul’s general hospitals. The questionnaire was divided into four parts, collecting demographic details and assessing knowledge, attitudes, and practices related to pharmacovigilance. Out of 391 respondents, 242 recognized the purpose of pharmacovigilance, yet only 167 could define it accurately. ADR reporting was performed by 126 HCPs, although 329 expressed readiness to adopt reporting procedures. Differences in professional roles significantly affected both knowledge and practice scores, with pharmacists achieving the highest levels (p < 0.001). The findings indicate substantial gaps in pharmacovigilance knowledge among HCPs and widespread underreporting of ADRs, highlighting the need for strengthened training and institutional support to enhance reporting practices.