Diabetes mellitus is a common condition that often leads to serious systemic complications. This study investigates the healing of infected wounds in hyperglycemia using formulations derived from plant materials such as Acacia nilotica, Trigonella foenumgraecum, Cyperus rotundus, and Cymbopogon proximus. A model of dexamethasone-induced hyperglycemia was created, followed by wound induction and the application of Streptococcus epidermidis-infected material from a patient with streptoderma. The findings indicate that aqueous emulsions containing these plant extracts positively affected the dysmetabolic changes associated with dexamethasone-induced hyperglycemia, such as decreased hepatic transaminase activity and normalized blood glucose levels. In addition, the composition of peripheral blood improved with increases in erythrocytes and hemoglobin and a reduction in leukopenia. These changes provide a supportive environment for wound healing, overcoming the inhibitory effects of dexamethasone-induced injury on regenerative processes.
