The creation of complete dentures using the additive tri-dimensional (3D) printing technique has gained popularity in recent years. Although the technological components of this relatively new technology are fully developed, the therapeutic aspects of its application are still being developed. Given their clinical use, the objective of this review was to evaluate the information currently available in the dental literature on the quality of 3D-printed complete dentures and highlight the areas that are both clear and unclear. Three databases were used for the electronic search: PubMed, Scopus, and Web of Science. The findings indicate that the clinical characteristics of complete dentures created using 3D printing additive technology have not been thoroughly investigated. The best technical parameters for the technological application and the mechanical properties of materials for 3D-printed removable dentures are hot topics. However, there are still many obstacles to overcome in the prosthetic rehabilitation of completely edentulous individuals using 3D-printed dentures. These include the attainment of optimal fitting to the denture-bearing region, adequate masticatory function, and the accurate vertical dimensions of occlusion when employing fully digital clinical procedures. The problem of achieving predictable aesthetic results remains unresolved. Further research is needed to clarify these aspects of the clinical performance of 3D-printed complete dentures.
