Written by Mohammed Al Abadie
Published on Vol 3, 2023
The Janus kinase (JAK) family and signal transducer and activator of transcription (STAT) proteins play a central role in intracellular signaling pathways and mediate the effects of more than 50 cytokines and growth factors. JAK inhibitors act by selectively targeting receptor-associated kinases, thereby suppressing the transduction of pro-inflammatory signals. With increasing evidence supporting the therapeutic potential of targeted agents, both systemic and topical JAK inhibitors have been inv
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Written by Andreea Fitero
Published on Vol 3, 2023
Diabetes patients are more vulnerable to COVID-19 infections, which can cause serious respiratory conditions. In this study, the effect of the antiviral medication with molnupiravir and favipiravir was compared in COVID-19 patients with underlying diabetes. The current investigation included a cohort of 100 people who had been diagnosed with diabetes, had a SARS-CoV-2 infection, and had been admitted sequentially. The antiviral drugs were administered to these patients according to regional reco
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Written by Majd Khashashneh
Published on Vol 3, 2023
Tooth bleaching is a less intrusive option than procedures linked to aesthetics. However, some are concerned about bleaching’s possible negative consequences, even though it is harmless when used on teeth and surrounding tissues. Based on this statement, the bleaching process must be utilized following a specific diagnostic, considering several elements, such as the kind of discolouration, the state of the teeth caused by food, the amount of reagents used, the patient’s age, the type of reaction
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Since the World Health Organisation declared COVID-19 a global pandemic, the number of hospitalisations and deaths caused by the virus has significantly increased. As additional Omicron sub-variants emerge, the likelihood of transmission increases, necessitating the need for new combination therapy to reduce the risk of coronavirus development. In this case, strengthening the immune system is essential to fight against extremely inflammatory diseases such as the cytokine storm caused by the coro
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Warfarin is recommended for patients who typically require anticoagulants. Myocardial infarction (MI), deep vein thrombosis (DVT), and stroke are among the common conditions for which warfarin is prescribed. Many physicians choose warfarin because it allows for direct monitoring. Additionally, it is available in a variety of dosages, allowing healthcare professionals to monitor the international normalized ratio (INR) and guarantee the best possible anticoagulation for their patients. Warfarin i
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Written by Katarzyna Guzek
Published on Vol 3, 2023
The hepatic enzymes CYP2D6 and CYP3A4 are primarily accountable for the transformation of the atypical antipsychotic medication aripirazole. It is recommended that CYP2D6-poor metabolizers adjust their dosage. Most adult patients handle aripiprazole well; however, occasionally, some people may experience negative side effects that lead to the medication being stopped. According to recent research, the effectiveness and safety of pharmacological therapy may be correlated with additional genes imp
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Written by Kumutha Theivasigamani
Published on Vol 3, 2023
The use of antidiabetic medications by patients with type-2 diabetes mellitus at primary care clinics in the Erode district of Tamil Nadu, India, a rural south Indian province, was investigated in a cross-sectional study. A standardized and validated questionnaire was used for the study, which lasted for one year. This medicine use assessment included 480 diabetic people who resided in a southern Indian state’s rural districts. Women (n = 279; 57.28%), married (n = 463; 95%), unemployed (n = 272
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The cause of the severe acute respiratory syndrome during the current pandemic was COVID-19 (SARS-CoV-2), which led to thousands of cases and significant death rates in all affected countries. The immune-therapy methods for COVID-19 treatment are the main topic of this review. Administration of interferon, convalescent plasma, intravenous immunoglobulin, monoclonal antibodies, cellular therapies, and immunomodulatory medications are the unique immunotherapeutic approaches. Immunotherapy is recom
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