Written by Mohammed Al Abadie
Published on Vol 3 , 2023
The Janus kinase (JAK) family and signal transducer and activator of transcription (STAT) proteins play a central role in intracellular signaling pathways and mediate the effects of more than 50 cytokines and growth factors. JAK inhibitors act by selectively targeting receptor-associated kinases, thereby suppressing the transduction of pro-inflammatory signals. With increasing evidence supporting the therapeutic potential of targeted agents, both systemic and topical JAK inhibitors have been inv
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Written by Andreea Fitero
Published on Vol 3 , 2023
Diabetes patients are more vulnerable to COVID-19 infections, which can cause serious respiratory conditions. In this study, the effect of the antiviral medication with molnupiravir and favipiravir was compared in COVID-19 patients with underlying diabetes. The current investigation included a cohort of 100 people who had been diagnosed with diabetes, had a SARS-CoV-2 infection, and had been admitted sequentially. The antiviral drugs were administered to these patients according to regional reco
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Written by Majd Khashashneh
Published on Vol 3 , 2023
Tooth bleaching is a less intrusive option than procedures linked to aesthetics. However, some are concerned about bleaching’s possible negative consequences, even though it is harmless when used on teeth and surrounding tissues. Based on this statement, the bleaching process must be utilized following a specific diagnostic, considering several elements, such as the kind of discolouration, the state of the teeth caused by food, the amount of reagents used, the patient’s age, the type of reaction
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Since the World Health Organisation declared COVID-19 a global pandemic, the number of hospitalisations and deaths caused by the virus has significantly increased. As additional Omicron sub-variants emerge, the likelihood of transmission increases, necessitating the need for new combination therapy to reduce the risk of coronavirus development. In this case, strengthening the immune system is essential to fight against extremely inflammatory diseases such as the cytokine storm caused by the coro
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Warfarin is recommended for patients who typically require anticoagulants. Myocardial infarction (MI), deep vein thrombosis (DVT), and stroke are among the common conditions for which warfarin is prescribed. Many physicians choose warfarin because it allows for direct monitoring. Additionally, it is available in a variety of dosages, allowing healthcare professionals to monitor the international normalized ratio (INR) and guarantee the best possible anticoagulation for their patients. Warfarin i
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Written by Katarzyna Guzek
Published on Vol 3 , 2023
The hepatic enzymes CYP2D6 and CYP3A4 are primarily accountable for the transformation of the atypical antipsychotic medication aripirazole. It is recommended that CYP2D6-poor metabolizers adjust their dosage. Most adult patients handle aripiprazole well; however, occasionally, some people may experience negative side effects that lead to the medication being stopped. According to recent research, the effectiveness and safety of pharmacological therapy may be correlated with additional genes imp
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Written by Kumutha Theivasigamani
Published on Vol 3 , 2023
The use of antidiabetic medications by patients with type-2 diabetes mellitus at primary care clinics in the Erode district of Tamil Nadu, India, a rural south Indian province, was investigated in a cross-sectional study. A standardized and validated questionnaire was used for the study, which lasted for one year. This medicine use assessment included 480 diabetic people who resided in a southern Indian state’s rural districts. Women (n = 279; 57.28%), married (n = 463; 95%), unemployed (n = 272
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The cause of the severe acute respiratory syndrome during the current pandemic was COVID-19 (SARS-CoV-2), which led to thousands of cases and significant death rates in all affected countries. The immune-therapy methods for COVID-19 treatment are the main topic of this review. Administration of interferon, convalescent plasma, intravenous immunoglobulin, monoclonal antibodies, cellular therapies, and immunomodulatory medications are the unique immunotherapeutic approaches. Immunotherapy is recom
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Lavender essential oil holds significant economic and therapeutic value, being extensively utilized in aromatherapy, perfumery, the food industry, and pharmaceuticals. In recent years, Bulgaria has emerged as the world’s leading producer of lavender, surpassing countries like France, the United Kingdom, China, India, and Spain. This study aims to: (1) analyze the chemical composition of lavender essential oil sourced from an agricultural plantation near Pomorie, Bulgaria; (2) conduct a descripti
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The immune condition of individuals is a key factor influencing the progression of COVID-19. Herbal remedies possessing immunomodulatory and anti-inflammatory properties may serve as effective complementary options alongside conventional treatments. This research aimed to identify and explore the immunomodulatory and anti-inflammatory components of Curcuma longa (C. longa) and elucidate their potential mechanisms of action in COVID-19. Biochemical constituents of C. longa rhizomes were systemati
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The COVID-19 pandemic has profoundly impacted various aspects of daily life, with education being one of the most affected sectors. In response, academic institutions in Jordan, as in many other countries, transitioned to virtual learning. After four semesters of online instruction, it became essential for both faculty members and pharmacy students to evaluate their experiences, preferences, and attitudes toward different modes of online teaching. This study aimed to examine the impact of the CO
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Written by Alistair Scott
Published on Vol 3 , 2023
In recent years, there has been a notable increase in the use of food supplements for the prevention and management of various chronic diseases. To better regulate the market, usage, and safety of these products, the European Commission has implemented harmonized regulations to ensure that food supplements provide accurate information and are not misleading. Nevertheless, excessive consumption, unsupervised use by patients, intake above recommended levels, and potential interactions with certain
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Resistance and toxicity remain major challenges in platinum-based anticancer therapies. This study aims to compare how the chemical structure and hydrolysis mechanisms influence the pharmacological activity and toxicological profiles of approved platinum drugs: Cisplatin, Carboplatin, Oxaliplatin, Nedaplatin, Lobaplatin, Heptaplatin, and Satraplatin. Carboplatin and Nedaplatin undergo hydrolysis via a two-step hydration process, ultimately generating the same active species as Cisplatin, namely
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A study on traditional antidiabetic remedies in Gunung Sari village, Bogor, Indonesia, investigated fifteen medicinal plants, which were collected and processed into crude extracts. Only three of these plants had been previously examined for their potential as dipeptidyl peptidase-IV (DPP-IV) inhibitors. Phytochemical quantification revealed total phenolic content (TPC) between 2.27±0.16 and 5.39±0.05 mg GAE/g extract, while total alkaloid content (TAC) ranged from 1.07±0.02 to 4.33±0.07 mg QE/g
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Microneedles represent a novel, minimally invasive, patient-friendly, and self-administered method for drug delivery that has attracted considerable interest. This study aimed to assess Jordanian pharmacists’ knowledge, awareness, and acceptance of microneedle technology and to determine factors predicting higher awareness levels. A cross-sectional survey was conducted online in Jordan during January and February 2023, and binary logistic regression was applied to identify predictors of greater
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In Bulgaria, dried herbs are regulated as food supplements under current legislation, allowing their sale in pharmacies, drugstores, and grocery stores. This study aimed to evaluate the morphological pharmacognostic characteristics of dried herb content and the supplementary information provided on the labels of Bulgarian food supplements, in accordance with key standards and regulatory guidelines concerning herbal substance and food supplement quality. A total of 91 herbal substances from 10 ma
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Type 2 diabetes mellitus (T2DM) represents a multifactorial metabolic disorder primarily marked by impaired insulin secretion and the presence of insulin resistance. If left untreated, T2DM inevitably progresses to various long-term complications. The emergence of novel therapeutic agents, such as Glucagon-like Peptide-1 receptor agonists (GLP-1 RAs), has introduced new possibilities for improved glycemic regulation and additional metabolic advantages. Pharmacogenetics, a branch of pharmacothera
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Clinical Pharmacy Services (CPS) are essential components of patient care in clinical settings. This study aimed to assess doctors’ perceptions of CPS at Universitas Sumatera Utara Hospital, Medan, Indonesia. Employing a descriptive mixed-methods design, the study utilized Importance–Performance Analysis (IPA) to collect both quantitative and qualitative data concurrently through semi-structured interviews guided by questionnaires. A total of 43 doctors participated in the study from October to
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Written by Maximilian Meyer
Published on Vol 3 , 2023
Coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus and represents a significant global health challenge. Although several therapeutic agents have shown promise for prevention or treatment, no specific drug has been definitively developed for COVID-19. Recently, natural products have emerged as potential candidates for COVID-19 management. This study investigated the potential effects of Coriandrum sativum L. (CSL) against COVID-19 using a network pharmacology approach. Active
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Pharmacovigilance plays a vital role in monitoring drug safety, minimizing adverse drug reactions (ADRs), and promoting the significance of reporting such events within healthcare systems. This study aimed to investigate the challenges and perspectives of pharmacists in Duhok, particularly those working in hospital and community pharmacy settings, regarding pharmacovigilance and ADR reporting. A cross-sectional survey was conducted from February 20 to March 20 2019 using a self-administered ques
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Written by Mette Sørensen
Published on Vol 3 , 2023
The inappropriate storage and disposal of unused medicines in homes have sparked worldwide concerns owing to their adverse effects on the environment, human health, and animal well-being. This research seeks to examine practices related to medication storage and disposal in southern Jordan, identify socio-demographic factors associated with the household accumulation of medicines, and assess public knowledge about proper medicine disposal. A cross-sectional study was carried out in southern Jord
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Failure to adhere to prescribed medications can result in numerous adverse clinical outcomes, such as elevated chances of relapse and disease recurrence. Through the delivery of personalized, face-to-face pharmaceutical care guidance, pharmacists have a vital role in fostering better medication adherence. In contemporary society, smartphones are among the most prevalent modes of communication. Therefore, incorporating a dedicated smartphone application for managing depression represents a promis
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Written by Marco Bianchi
Published on Vol 3 , 2023
The use of multiple medications concurrently is linked to the prescribing of potentially unsuitable drugs and preventable adverse effects related to medicines. An innovative intervention directed by pharmacists seeks to detect and address unsuitable prescribing in elderly individuals experiencing polypharmacy. To perform an initial evaluation of the intervention's practicality in a primary care environment, examining whether particular elements of the intervention's protocols and operati
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Written by Carlos M. Alvarez
Published on Vol 3 , 2023
The global COVID-19 pandemic imposed substantial extra demands on healthcare systems. Yet, the consequences of this ongoing and fluctuating strain on pharmacists' wellbeing, burnout levels, and resilience have not been investigated in depth. To assess variations over time in resilience, burnout, and wellbeing among pharmacists, tracking from June 2020 through March 2021. An electronic questionnaire was shared via social media platforms during June/July 2020. Eligibility extended to all UK ph
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Written by Jonathan P. Reed
Published on Vol 3 , 2023
Cancer therapies based on reactive oxygen species (ROS) show great potential by disrupting the redox equilibrium in tumor cells through multiple pathways. In particular, approaches that combine physical and biochemical activation have gained attention due to their precise spatiotemporal control, minimal toxicity, and high treatment efficiency. In this study, we developed a nanogel complex that functions as a multilevel ROS-amplifying system by incorporating chloroperoxidase (CPO) into gold nanor
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Written by Hiroshi Tanaka
Published on Vol 3 , 2023
Standardisation is a well-established approach to managing risks, involving the creation and application of detailed instructions for specific activities. Within community pharmacy settings, the use of Standardised Operating Procedures (SOPs) is compulsory and viewed as vital for maintaining patient safety and service quality. The objective of this research was to explore the extent to which community pharmacists (CPs) follow SOPs during the process of reviewing prescriptions clinically, as well
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