Written by Gonçalo Januário
Published on Vol 2 Issue 1, 2022
Glioblastoma multiforme (GBM) is the most common form of primary malignant brain tumor in the central nervous system (CNS). While these tumors are commonly found in supratentorial areas, they rarely occur in infratentorial regions, accounting for approximately 0-3.4% of all primary GBMs. The occurrence of GBMs in adults is relatively rare, with even fewer cases reported in the elderly population. Typically, these tumors present as rapidly expanding lesions in the posterior fossa, often leading t
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Written by Ayse Nur Akatli
Published on Vol 2 Issue 1, 2022
This study focused on investigating the roles of p16INK4a, p14ARF, and p53 proteins in the development of squamous cell carcinoma of the lip. A total of 46 tissue samples were analyzed, which included 19 cases of squamous cell carcinoma of the lip, 14 cases of actinic cheilitis, and 13 samples of normal lip mucosa. The study also evaluated protein expression in the epithelial tissue surrounding the tumors. Notably, p16INK4a levels were significantly higher in actinic cheilitis compared to normal
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Written by Abubakr Mohammed Ali Nasr
Published on Vol 2 Issue 1, 2022
Choriocarcinoma is a highly aggressive neoplasm of trophoblastic origin, which can be classified as either gestational or non-gestational. The majority of cases are gestational, arising from either normal or abnormal pregnancies. This review examines the prevalence and risk factors of choriocarcinoma by analyzing the available literature. The research team conducted a comprehensive search of databases such as ScienceDirect, PubMed, EBSCO, Web of Science, Cochrane Library, and Scopus. They screen
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Written by Lauro FigueroaValverde
Published on Vol 2 Issue 1, 2022
While various drugs are available for the treatment of cancer, many of them are associated with side effects such as high blood pressure, liver damage, and erectile dysfunction. In the search for safer treatment options, some dibenzo derivatives have shown potential against cancer. However, conflicting reports indicate that certain dibenzo compounds might worsen the disease. This inconsistency could be due to structural differences among the dibenzo derivatives. To clarify this, the present stud
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Written by Mahmoud Mohamed Ahmed
Published on Vol 2 Issue 1, 2022
Numerous studies, including our previous research, have investigated the effects of different plasma sources and their respective doses on both healthy and cancerous cells. These studies aimed to interpret the potential mechanisms behind cancer treatment involving plasma and its interactions with cells. Plasma has been shown to play an important role in the outcomes of cancer cell treatment through several investigations, including genetic, biochemical, and immunological analysis. This body of w
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Written by M. Opiyo
Published on Vol 2 Issue 1, 2022
Radical hemithoracic radiotherapy (RHRT) offers a promising approach to extend survival in patients with malignant pleural mesothelioma. In this study, we examined how RHRT influences the systemic metabolic profile and whether these changes correlate with clinical outcomes. Nineteen patients underwent RHRT at 50 Gy delivered over 25 fractions. Serum metabolite levels were analyzed before and after treatment using targeted liquid chromatography-tandem mass spectrometry. Statistical modeling, incl
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Written by J.H. Kim
Published on Vol 2 Issue 1, 2022
Precision oncology faces two major hurdles: rapidly pinpointing actionable molecular alterations and making such targeted interventions accessible to a wide patient population. We report a four-year experience of the Molecular Tumor Board (MTB) at the Comprehensive Cancer Center Freiburg, Germany, highlighting workflow refinements and practical implementation strategies. This retrospective study includes 488 patients evaluated from February 2015 to December 2018. The MTB provided personalized mo
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Written by M. R. Islam
Published on Vol 2 Issue 1, 2022
Next-generation sequencing (NGS) has been integrated into routine cancer care in Japan, supported by coverage from the national universal health-care system. However, this reimbursement currently applies only to patients who have completed standard therapeutic options. In this retrospective analysis, we reviewed data from 221 individuals who received the Foundation One CDx (F1CDx) test at our university hospital. Each patient’s sequencing results were evaluated by a molecular tumor board (MTB) t
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Written by P. Davies
Published on Vol 2 Issue 1, 2022
Natural killer (NK) cells are a promising avenue for cancer immunotherapy, but efficient clinical-scale production remains challenging. Here, we present an optimized protocol for the activation and expansion of NK cells (NKAE) and its validation under clinical-grade conditions. NK cells were expanded from either total peripheral blood mononuclear cells (PBMCs) or CD45RA+ subsets using irradiated K562 feeder cells expressing IL15-41BBL or IL21-41BBL, with culture media including RPMI-1640, SCGM,
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Written by L. Andersen
Published on Vol 2 Issue 1, 2022
High-grade B-cell lymphomas with concurrent MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) represent an aggressive subgroup of B-cell malignancies with limited therapeutic options and poor survival outcomes. Despite growing recognition of the tumor microenvironment (TME) as a determinant of prognosis in hematologic cancers, its role in HGBL-DH/TH has not been systematically evaluated. Here, we characterize the adaptive immune landscape in 47 HGBL-DH/TH cases compared with 27 triple-negativ
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Written by D. Fernando
Published on Vol 2 Issue 1, 2022
Surgical resection is the standard therapy for early-stage hepatocellular carcinoma (HCC) in patients with preserved liver function, yet recurrence remains common. While clinical and pathological factors contribute to recurrence risk, HCC is characterized by complex genomic alterations that create significant molecular heterogeneity, which is not yet fully understood. This study sought to combine clinical predictors with molecular insights through next-generation sequencing (NGS) and loss of het
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Written by S. K. Lim
Published on Vol 2 Issue 1, 2022
Brain metastases (BMs) frequently involve infratentorial regions, yet the clinical implications of metastases in these areas remain unclear. In this retrospective analysis, 1102 patients with a total of 4365 BM lesions were examined. MRI scans were processed using voxel-wise mapping to create normalized tumor frequency heatmaps, and Analysis of Differential Involvement (ADIFFI) identified clusters with statistical significance. Survival outcomes were evaluated using Kaplan-Meier analysis and Cox
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