Written by Leela Prasad Kowtharapu
Published on Vol 2, 2022
This study outlines an RP-HPLC technique for quantifying azelnidipine and metoprolol succinate in a synthetic mixture. Azelnidipine, a calcium channel blocker, and metoprolol succinate, a beta-blocker, are both used for the management of hypertension. The method was optimized using a Shimadzu HPLC LC2010 system, equipped with a UV-VIS detector and a binary gradient system. A Hibar ODS C18 5 µm column (250 x 4.6 mm) was used for separation in isocratic mode, with a mobile phase consisting of meth
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Written by Khagga Bhavya Sri
Published on Vol 2, 2022
Baricitinib is a novel therapeutic agent recently approved for the treatment of moderate to severe rheumatoid arthritis, severe alopecia areata, and since 2022, COVID-19 in hospitalized adults requiring supplemental oxygen. This drug acts as a selective inhibitor of Janus kinase 1 and 2. This study aimed to establish and validate a stability-indicating UV spectroscopic method for the measurement of baricitinib in both bulk and formulated forms. A straightforward, precise, and cost-effective UV m
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Written by Oluwatoyin A. Adeleke
Published on Vol 2, 2022
The main objective of this study was to develop liquisolid compacts containing rifampicin and quercetin with enhanced gastrointestinal absorption and dissolution characteristics. To achieve the desired formulations, non-volatile liquid carriers such as propylene glycol, PEG 200, and Tween 20 were selected due to their superior drug solubility properties. The liquisolid formulations were subsequently blended with carrier and coating materials to produce a free-flowing and compressible powder. Avi
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Written by Ahsan Zamir Siddiqi
Published on Vol 2, 2022
A straightforward and highly sensitive isocratic reversed-phase HPLC technique has been developed for the detection and quantification of ciprofloxacin in pharmaceutical formulations, which has been validated following ICH guidelines. This study introduces a straightforward, cost-effective HPLC technique that delivers accurate results, a low limit of quantification (LOQ), and reduced analysis time. The separation process was performed on a C18 reversed-phase column, using a mobile phase of aceto
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The transdermal drug delivery system (TDDS) has emerged as a significant advancement in drug administration, offering numerous benefits in pharmaceutical treatments. Transdermal patches, which deliver drugs through the skin, provide a systemic effect by allowing the drug to penetrate the dermis. This approach offers advantages such as continuous drug absorption, more stable plasma concentrations, reduced first-pass metabolism, fewer side effects, ease of use, and the ability to terminate treatme
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A rapid, simple, and robust reverse-phase HPLC method was developed and validated for the quantification of related substances in dolutegravir 10 mg dispersible tablets. This study primarily aimed to establish a new RP-HPLC method to quantify impurity B (a degradation impurity) as a related substance, following USP guidelines. Chromatographic separation was performed using a phenyl-hexyl column (250 × 4.6 mm, 5µ) with a mobile phase consisting of 45% buffer (sodium dihydrogen phosphate dihydrate
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Written by Sobhy M. El-adl
Published on Vol 2, 2022
This study proposes a numerical approach based on spectroscopic data combined with partial least squares (PLS) multivariate analysis to simultaneously quantify quercetin and rifampicin in raw materials and liquisolid formulations. Spectral measurements were obtained for rifampicin and quercetin over a linear concentration range of 2–10 µg/ml for each compound. A total of 25 simulated mixtures were generated, including 16 calibration and 9 validation sets, using a wavelength interval of λ = 15 nm
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Written by Liza Tybaco Billones
Published on Vol 2, 2022
The pursuit of next-generation non-steroidal anti-inflammatory drugs (NSAIDs) remains a critical focus in pharmaceutical research, given that over a billion individuals experience pain and inflammation. A key strategy in this effort involves developing a quantitative correlation between the anti-inflammatory potential and the molecular descriptors of cyclooxygenase-2 (COX-2) inhibitors, which will facilitate the identification and advancement of novel NSAIDs that minimize adverse effects associa
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Written by Maja Simonoska Crcarevska
Published on Vol 2, 2022
In recent years, pharmaceutical companies have focused on controlled-release dosage forms, including solid, semi-solid, and topical preparations, due to their improved efficacy and better patient acceptance. However, transdermal drug delivery systems face challenges for compounds intended for skin application. Traditional topical treatments often have drawbacks such as unpleasant odors, greasiness, and skin irritation. In some cases, topical treatments do not achieve sufficient systemic circulat
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