Written by Leela Prasad Kowtharapu
Published on Vol 2 , 2022
This study outlines an RP-HPLC technique for quantifying azelnidipine and metoprolol succinate in a synthetic mixture. Azelnidipine, a calcium channel blocker, and metoprolol succinate, a beta-blocker, are both used for the management of hypertension. The method was optimized using a Shimadzu HPLC LC2010 system, equipped with a UV-VIS detector and a binary gradient system. A Hibar ODS C18 5 µm column (250 x 4.6 mm) was used for separation in isocratic mode, with a mobile phase consisting of meth
Read More
Written by Khagga Bhavya Sri
Published on Vol 2 , 2022
Baricitinib is a novel therapeutic agent recently approved for the treatment of moderate to severe rheumatoid arthritis, severe alopecia areata, and since 2022, COVID-19 in hospitalized adults requiring supplemental oxygen. This drug acts as a selective inhibitor of Janus kinase 1 and 2. This study aimed to establish and validate a stability-indicating UV spectroscopic method for the measurement of baricitinib in both bulk and formulated forms. A straightforward, precise, and cost-effective UV m
Read More
Written by Oluwatoyin A. Adeleke
Published on Vol 2 , 2022
The main objective of this study was to develop liquisolid compacts containing rifampicin and quercetin with enhanced gastrointestinal absorption and dissolution characteristics. To achieve the desired formulations, non-volatile liquid carriers such as propylene glycol, PEG 200, and Tween 20 were selected due to their superior drug solubility properties. The liquisolid formulations were subsequently blended with carrier and coating materials to produce a free-flowing and compressible powder. Avi
Read More
Written by Ahsan Zamir Siddiqi
Published on Vol 2 , 2022
A straightforward and highly sensitive isocratic reversed-phase HPLC technique has been developed for the detection and quantification of ciprofloxacin in pharmaceutical formulations, which has been validated following ICH guidelines. This study introduces a straightforward, cost-effective HPLC technique that delivers accurate results, a low limit of quantification (LOQ), and reduced analysis time. The separation process was performed on a C18 reversed-phase column, using a mobile phase of aceto
Read More
The transdermal drug delivery system (TDDS) has emerged as a significant advancement in drug administration, offering numerous benefits in pharmaceutical treatments. Transdermal patches, which deliver drugs through the skin, provide a systemic effect by allowing the drug to penetrate the dermis. This approach offers advantages such as continuous drug absorption, more stable plasma concentrations, reduced first-pass metabolism, fewer side effects, ease of use, and the ability to terminate treatme
Read More
A rapid, simple, and robust reverse-phase HPLC method was developed and validated for the quantification of related substances in dolutegravir 10 mg dispersible tablets. This study primarily aimed to establish a new RP-HPLC method to quantify impurity B (a degradation impurity) as a related substance, following USP guidelines. Chromatographic separation was performed using a phenyl-hexyl column (250 × 4.6 mm, 5µ) with a mobile phase consisting of 45% buffer (sodium dihydrogen phosphate dihydrate
Read More
Written by Sobhy M. El-adl
Published on Vol 2 , 2022
This study proposes a numerical approach based on spectroscopic data combined with partial least squares (PLS) multivariate analysis to simultaneously quantify quercetin and rifampicin in raw materials and liquisolid formulations. Spectral measurements were obtained for rifampicin and quercetin over a linear concentration range of 2–10 µg/ml for each compound. A total of 25 simulated mixtures were generated, including 16 calibration and 9 validation sets, using a wavelength interval of λ = 15 nm
Read More
Written by Liza Tybaco Billones
Published on Vol 2 , 2022
The pursuit of next-generation non-steroidal anti-inflammatory drugs (NSAIDs) remains a critical focus in pharmaceutical research, given that over a billion individuals experience pain and inflammation. A key strategy in this effort involves developing a quantitative correlation between the anti-inflammatory potential and the molecular descriptors of cyclooxygenase-2 (COX-2) inhibitors, which will facilitate the identification and advancement of novel NSAIDs that minimize adverse effects associa
Read More
Written by Maja Simonoska Crcarevska
Published on Vol 2 , 2022
In recent years, pharmaceutical companies have focused on controlled-release dosage forms, including solid, semi-solid, and topical preparations, due to their improved efficacy and better patient acceptance. However, transdermal drug delivery systems face challenges for compounds intended for skin application. Traditional topical treatments often have drawbacks such as unpleasant odors, greasiness, and skin irritation. In some cases, topical treatments do not achieve sufficient systemic circulat
Read More
Anlotinib, a multitarget tyrosine kinase inhibitor, has demonstrated notable activity against esophageal squamous cell carcinoma (ESCC). This study summarizes real-world outcomes comparing chemoradiotherapy (CRT) combined with anlotinib versus CRT alone in individuals who developed lymph node relapse following curative surgery. Records of patients with nodal recurrence treated with CRT with or without anlotinib between January 2017 and December 2019 were retrospectively reviewed. Tumor response,
Read More
Pulmonary hypertension (PH) is a life-threatening disease of the pulmonary vasculature for which effective therapeutic options remain scarce. Although ginsenoside Rg1 has shown beneficial activity in alleviating PH, the molecular basis of its action has not been fully clarified. This work aimed to elucidate the signaling mechanisms through which ginsenoside Rg1 improves PH. A rat model of PH was used to evaluate the therapeutic impact of ginsenoside Rg1 via cardiopulmonary hemodynamic analysis a
Read More
Written by Daniel Rivera
Published on Vol 2 , 2022
Colorectal cancer (CRC) ranks as the third most prevalent malignancy worldwide, and effective treatment options remain limited. Perillaldehyde (PAH), a key bioactive component derived from Perilla, has shown promise in managing CRC, yet its underlying mechanisms are not fully understood. This work investigates the anti-CRC potential of PAH and elucidates its mode of action, aiming to support its development as a candidate therapeutic agent. For the in vitro portion, we employed CCK-8 assays, col
Read More
Diabetic kidney disease (DKD) is one of the primary causes of long-term loss of renal function internationally. In recent years, bile acids (BAs) have emerged as important metabolic signals influencing glucose control and kidney physiology. This project explored how disturbances in BA pathways contribute to DKD advancement. Plasma BA concentrations were quantified in healthy individuals (HC), subjects with type 2 diabetes mellitus (T2DM), and patients diagnosed with DKD using ultra-high-performa
Read More
Propofol remains a widely applied intravenous anesthetic in children. Newer agents, including ciprofol and remimazolam, produce little to no injection discomfort and maintain more consistent hemodynamics. This investigation assessed how these three drugs influence the ability to provoke arrhythmias in pediatric supraventricular tachycardia (SVT). Clinical records of children with SVT who received radiofrequency ablation under general anesthesia between May 2020 and June 2024 were reviewed. After
Read More
IgA vasculitis nephritis (IgAVN) is a frequent form of secondary glomerular disease in childhood. Although consensus documents generally acknowledge the therapeutic value of cyclophosphamide (CYC), guidance regarding tacrolimus (TAC) and mycophenolate mofetil (MMF) remains variable. Existing data indicate that TAC can work safely and effectively in IgAVN, but the long-term influence of different immunosuppressants is still not clearly defined. This study was designed to compare TAC, CYC, and MMF
Read More
This investigation sought to identify the median effective dose (ED50) and the 90% effective dose (ED90) of ciprofol that can reliably provide sedation for the induction of general anesthesia in children, refine dosing recommendations, and support clinical decision-making. Children 3–12 years old scheduled for elective procedures requiring general anesthesia and endotracheal intubation were recruited. The initial participant received 0.4 mg/kg of intravenous ciprofol. Dose adjustments for all fo
Read More
Excess body weight is frequently associated with suboptimal endometrial readiness and poorer reproductive success in frozen-thawed embryo transfer (FET) cycles. Administering a depot gonadotropin-releasing hormone agonist (GnRH-a) prior to starting hormone replacement therapy (HRT) has been suggested to enhance endometrial performance through several biological pathways; however, whether this strategy benefits overweight or obese individuals has not been clearly determined. This retrospective an
Read More
Glucocorticoids are widely used in managing severe drug-induced liver injury (DILI) to enhance clinical improvement and reduce the length of hospital stay, yet they may elevate susceptibility to infections. This work aimed to build a model capable of forecasting infection following glucocorticoid administration in individuals with DILI. A retrospective review was carried out on patients diagnosed with severe DILI who received glucocorticoid treatment at the Fifth Medical Center of the Chinese Pe
Read More
Baolier capsule (BLEC), a traditional Mongolian formulation, is prescribed for managing hypercholesterolemia and atherosclerosis (AS). Yet, its therapeutic efficacy, key constituents, and molecular actions in these disorders remain insufficiently defined. This work sought to clarify the pharmacodynamic profile of BLEC, identify its principal bioactive molecules, and delineate its mechanisms against hypercholesterolemia and AS. Liver-specific LXRα knockout ApoE−/− mice were generated via adeno-as
Read More
Written by Diana Brkovic
Published on Vol 2 , 2022
IgA nephropathy (IgAN) remains a major cause of renal failure and mortality, and available treatments are still limited. Gui-qi-yi-shen (GQYS) granules—an established traditional Chinese medicinal formula—have long been used for IgAN, yet the molecular basis of their therapeutic effects is not fully defined. This study aimed to clarify how GQYS mediates its beneficial actions in IgAN. Eight-week-old Itgam-IRES-hCD89 mice were assigned to four experimental groups: IgAN, low-dose GQYS (GQYS-L, 5.2
Read More
Our esteemed publisher is committed to advancing medical knowledge through rigorous research dissemination. We exclusively accept submissions related to the field of medicine.
Our journals provide a platform for clinicians, researchers, and scholars to share groundbreaking discoveries, clinical insights, and evidence-based practices. By maintaining this specialized focus, we ensure that their publications contribute significantly to the advancement of healthcare worldwide.
