Volume 3 (2023)

Taxol, derived from the plant alkaloid paclitaxel, is a prominent anticancer agent. It acts by inhibiting microtubule formation and preventing cancer cell division. The intravenous administration of Taxol has been well established, particularly in the treatment of solid tumors. However, prolonged use of the drug often leads to reduced efficacy due to the emergence of resistance in cancer cells. Furthermore, the side effects of Taxol can vary depending on individual factors such as age, genetics,

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The objective of this study was to evaluate the hepatoprotective effects of resveratrol (RSV) and gamma-glutamylcysteine (γ-GC) against liver damage induced by azathioprine (AZA), with potential implications for combining these compounds with immunosuppressive therapies. The study lasted for 4 weeks and included 50 male Wistar albino rats divided into five groups: a control group treated with normal saline, an AZA group given AZA at 10 mg/kg orally, an RSV group treated with both AZA and RSV (8

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Dolutegravir sodium is an effective antiretroviral medication used for the treatment of HIV. The drug is classified as BCS class II, indicating its low solubility at the typical gastric pH. The purpose of this research was to identify and optimize the key operational and formulation factors affecting the drug’s properties, using a 32-factorial design. Nanosuspensions were prepared using PVP K30, polyvinyl alcohol, polxammer 407, and polxammer 188. The study focused on polymer concentration as th

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Non-steroidal anti-inflammatory drugs (NSAIDs) have long been recognized as one of the most commonly used agents. However, their adverse effects on various organs are well-documented. This review focuses on the development of acetamide derivatives that retain their anti-inflammatory effects while selectively inhibiting COX-II. Several literature sources emphasize the importance of these heterocyclic compounds in the treatment of inflammatory conditions, recognizing their therapeutic value in thi

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This research focused on establishing a new and highly sensitive UV-spectrophotometric approach for quantifying dapagliflozin in tablet dosage form while ensuring comprehensive validation of analytical parameters following ICH guidelines. The maximum absorbance (λmax) of dapagliflozin was identified at 220 nm using a UV-Vis spectrophotometer equipped with a 1 cm quartz cell. A stock solution of 1000 μg/ml was prepared using a solvent system consisting of methanol and water in a ratio of 15:85, a

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This study aimed to evaluate the method of the calibration curve (MCC) and the external reference standard method (MRS) to assess the accuracy and precision to validate the UV-spectrophotometric technique for quantifying diazepam at λmax = 328 nm in 95% ethanol. Selectivity was confirmed by the absence of absorbance at λmax = 328 nm in the UV spectrum of the blank solution, whereas this wavelength was distinctly observed for diazepam. The experimental data were analyzed using linear regression,

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This research explores a novel approach to enhance the absorption of biologically active compounds with poor bioavailability by combining partially soluble arabinogalactan polysaccharides with chitosan-based polysaccharides. The study focuses on a bioactive polymer matrix composed of chitosan succinate, succinic anhydride, and arabinogalactan with covalently unbound dihydroquercetin, with respective weight proportions of 3.0-5.0, 2.0-4.0, 15.0-20.0, and 3.0-5.0. These elements act as specialized

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