Written by Claire Martin
Published on Vol 6 Issue 1, 2026
Antimicrobial resistance, along with fungal contamination, continues to pose significant risks to public health and agricultural systems, underscoring the urgent need for novel alternatives. Bioactive compounds derived from plants represent a promising source, and their effectiveness may be further improved through nanoformulation strategies. This work evaluated the antimicrobial activity of Ocotea indecora essential oil and its corresponding nanoemulsion. GC-MS analysis of the essential oil ide
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Written by Ravi Kumar
Published on Vol 6 Issue 1, 2026
The present work sought to clarify both the therapeutic activity and the mechanistic basis of indirubin in acute lymphoblastic leukemia (ALL) by integrating network pharmacology approaches with experimental validation. Genes associated with indirubin and ALL were collected from publicly accessible databases to identify potential targets. Protein–protein interaction (PPI) networks were constructed and analyzed in Cytoscape to isolate core genes. Functional enrichment analyses, including Gene Onto
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Written by Lucas Meyer
Published on Vol 6 Issue 1, 2026
YK-4-279 is an emerging anticancer compound that has demonstrated activity across a range of tumor models. Osteosarcoma (OS), a highly aggressive bone malignancy predominantly diagnosed in adolescents, still lacks satisfactory therapeutic options. A detailed investigation of how YK-4-279 functions in OS is essential for determining its potential clinical relevance. Therefore, the present study aimed to evaluate its effects on OS cell viability, proliferation, DNA damage, cell cycle regulation, a
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Written by Ahmed Mansour
Published on Vol 6 Issue 1, 2026
This study evaluated interpolyelectrolyte complexes (IPECs) formed from Eudragit® EPO and Eudragit® L100 as potential platforms for gastroretentive drug delivery systems (GRDDS), using metronidazole (MZ) and acyclovir (ACR) as representative model drugs. The prepared Eudragit® EPO/L100 IPECs, obtained under different pH conditions, exhibited variable swelling behavior in simulated fasted gastric fluid (0.1 M HCl) while retaining structural integrity for 6 h. Changes in the internal microenvironm
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Written by Daniel Fischer
Published on Vol 6 Issue 1, 2026
The central aim pursued in this work was to investigate and assess the capacity of designated excipients to yield efficacious sustained-release omeprazole platforms. Toward this end, six distinct excipients were chosen (lactose monohydrate, medium-viscosity alginic acid, Avicel® PH-101, Avicel® PH-102, PVP K-30, and magnesium stearate). Selection was guided by criteria grounded in the physicochemical attributes of these materials (e.g., minimal toxicity) and their economic accessibility. Two exc
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Written by Hiroshi Tanaka
Published on Vol 6 Issue 1, 2026
Even though COVID-19 is no longer considered a pandemic, SARS-CoV-2 continues to evolve through frequent mutations, giving rise to new variants and maintaining its relevance as a global public health concern. The lack of effective, orally available antiviral treatments complicates clinical management, underscoring the need to develop broad-spectrum antiviral agents capable of addressing current and future viral outbreaks. In this study, a molecular docking approach was applied to evaluate the bi
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Written by Fatima Zahra Amrani
Published on Vol 6 Issue 1, 2026
Nitrofurantoin (NITRO), a time-honored antibiotic prescribed for urinary tract infections, relies on nitroreductases for its activation. This mode of action has spurred its evaluation for drug repurposing aimed at controlling and managing breast cancer, a malignancy that expresses a nitroreductase gene. NITRO-loaded cubosomes were prepared by hot homogenization using a 23 full-factorial design. The variables examined consisted of the drug-to-oily phase proportion (1:10 and 2:10), the oily-to-aqu
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Written by Maria Hernandez
Published on Vol 6 Issue 1, 2026
Individuals with HER2-positive breast cancer treated with chemotherapy and targeted agents, such as anthracyclines and trastuzumab, are at heightened risk of developing cardiotoxic effects that may progress to long-term cardiovascular complications. Early identification of predictive biomarkers is therefore critical for timely clinical intervention. Circulating microRNAs (miRNAs), which regulate gene expression and play important roles in cardiovascular biology, have recently been proposed as po
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Written by Wei Chen
Published on Vol 6 Issue 1, 2026
Breast cancer is the most frequently diagnosed malignancy in women and remains the leading cause of cancer-related mortality worldwide. The treatment of invasive forms of this disease is particularly problematic due to the toxicity and side effects associated with conventional chemotherapeutic agents. Natural products have therefore gained attention as promising candidates for anticancer drug development; among them, the homoisoflavonoid brazilin has been reported to exhibit several biological a
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Written by Nguyen Thanh Huy
Published on Vol 6 Issue 1, 2026
Persistent microbial antibiotic resistance, together with the growing frequency of pandemics, fuels the demand for new antimicrobial agents (AntAg). Given the AntAg shortfall, studies aimed at developing rapid strategies for identifying novel drug candidates are highly relevant. The present investigation is designed to carry out an in silico examination of the biological activity spectrum along with the molecular binding interactions of four structurally distinct levofloxacin (Lvf) variants enga
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Written by Michael Turner
Published on Vol 6 Issue 1, 2026
Colorectal cancer (CRC) is one of the most common malignancies worldwide, and currently available treatments are often associated with notable adverse effects. Cannabidiol (CBD), a bioactive constituent of Cannabis sativa, has exhibited promising antitumor potential. However, its precise molecular mechanisms remain unclear. Therefore, this study aims to investigate the mechanism of action of cannabidiol in colorectal cancer using a network pharmacology approach supported by molecular docking ana
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Written by Carlos Ramirez
Published on Vol 6 Issue 1, 2026
The objective of this investigation was to construct a binary nanodrug-delivery system functionalized with aptamers (APs) and transferrin (Tf), and co-loaded with daunorubicin (Drn) and luteolin (Lut) for leukemia therapy. Ligand molecules bearing oligonucleotide AP and Tf were individually designed and fabricated. AP-functionalized Drn-loaded nanoparticles (AP-Drn NPs) along with Tf-Lut NPs were generated through a self-assembly process. An AP- and Tf-co-functionalized, Drn- and Lut-co-loaded n
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Written by James Walker
Published on Vol 6 Issue 1, 2026
Breakthroughs in nanoscience have sparked a radical rethinking of how therapeutically valuable natural compounds are applied in medicine. This investigation seeks to engineer a nanoformulated natural product for potent cancer therapy. Toward this end, mesoporous silica nanoparticles (MSNPs) were prepared, thoroughly characterized, and then loaded with caffeine to construct a site-specific drug carrier, referred to as caffeine-coated nanoparticles (CcNPs). Computational docking simulations were p
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Written by Bruno Martins
Published on Vol 6 Issue 1, 2026
Sirolimus is an immunosuppressive medication commonly used after solid organ transplantation. Its use is characterized by a narrow therapeutic index and fluctuating pharmacokinetic exposure, making it essential to pinpoint the sources of this variability and to devise individualized treatment strategies. The goal of this work was to conduct a population pharmacokinetic (PK) evaluation of sirolimus in adult liver transplant recipients and to generate dosage recommendations tailored to patient-spe
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Written by Jinwoo Park
Published on Vol 6 Issue 1, 2026
The aim was to examine how the cationic nanocarrier leciplex (LPX) could boost the oral bioavailability of vancomycin hydrochloride (VAN) through enhancement of its permeation across the intestinal wall. A D-optimal design was employed to evaluate the impact of several variables—namely, lipid molar ratio, cationic surfactant molar ratio, cationic surfactant type, and lipid type—on the attributes of LPX, such as entrapment efficiency (EE%), particle size (P.S.), polydispersity index (P.I.), zeta
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Written by Ahmed El-Kholy
Published on Vol 6 Issue 1, 2026
Metal-derived nanoparticles have attracted interest for numerous medical applications due to their functional, physical, and chemical properties, including their ability to fight bacteria, reduce inflammation, and support tissue regeneration. This investigation sought to determine the curative capacity of novel silver carbonate nanostructures to facilitate wound closure and their antibacterial activity against Pseudomonas chengduensis and Staphylococcus aureus. For this research, Ag2CO3 nanopart
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Written by Claire Dupont
Published on Vol 6 Issue 1, 2026
Gold nanoparticles possess the capacity to convert incident radiation into thermal energy through plasmonic effects, a behavior modulated by both particle size and geometry. This intrinsic property enables the spatiotemporal orchestration of active payload release from polymer-based pharmaceutical carriers, thereby reducing undesirable side reactions and unintended leakage. Three-dimensional printing, specifically the vat photopolymerization modality, has emerged as a powerful fabrication route
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