Written by Aleda M H Chen
Published on Vol 3 , 2023
Moringa oleifera (M. oleifera) and Moringa concanensis (M. concanensis), both belong to the Moringaceae family and are commonly recognized as drumstick trees. M. oleifera, often referred to as the “miracle tree,” has been valued for its extensive health benefits for centuries. M. concanensis, also known locally as Kattumurungai, is another vital medicinal plant used for treating conditions such as skin tumors, fatigue, high blood pressure, jaundice, and diabetes. This study compares the pharmaco
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Written by Zulikhan Khaditovna Alkhanova
Published on Vol 3 , 2023
In Russia, stroke is the second leading cause of mortality (21.4%), following coronary heart disease (25.7%). The recurrence rate of strokes remains high, constituting around 25% of the cases of acute cerebral circulatory disturbances. In addition, up to 80% of stroke survivors experience lasting disabilities. Consequently, the development of effective methods for the prevention of recurrent strokes is a vital goal for medical science. This study investigated the potential of phytotherapy in the
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Written by Ruzanna Simonyan
Published on Vol 3 , 2023
In this study, isoforms of NPC-Fe(III) complexes were extracted and purified from Helianthus tuberosus (Armenian Jerusalem artichoke), Solanum tuberosum (potato), and Daucus sativus (carrot). For the 1st time, the physicochemical properties of these complexes were determined, including their specific content, O₂⁻-producing activity, steady-state concentration of O₂⁻, and fluorescence intensity. These complexes exhibited peak optical absorbance in both the visible and UV spectra. Hybrid complexes
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Written by Michael Hultström
Published on Vol 3 , 2023
The kidneys are essential for filtering and eliminating waste from the body, but their function can be compromised by oxidative stress caused by reactive oxygen species. This study investigated the protective effects of Gum Arabic (GA), an FDA-approved dietary fiber, against aluminum chloride (AlCl₃)-induced kidney injury in rats, focusing on XRCC1 gene expression and Ki67 and p53 immunoreactivity. A total of 20 male Wistar rats were allocated into four groups (n = 20). The control group (group
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Written by Alexandra Sergeevna Tsiganock
Published on Vol 3 , 2023
Diabetes mellitus is a common condition that often leads to serious systemic complications. This study investigates the healing of infected wounds in hyperglycemia using formulations derived from plant materials such as Acacia nilotica, Trigonella foenumgraecum, Cyperus rotundus, and Cymbopogon proximus. A model of dexamethasone-induced hyperglycemia was created, followed by wound induction and the application of Streptococcus epidermidis-infected material from a patient with streptoderma. The f
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This study used network pharmacology strategies combined with multi-pathway analysis to investigate the potential bioactive constituents and underlying therapeutic mechanisms of the hospital-prepared Yinaoan capsule (YNA) for epilepsy treatment. The active compounds in YNA were systematically retrieved from multiple resources, including the traditional Chinese medicine system pharmacology database (TCMSP), the traditional Chinese medicines integrated database (TCMID), the encyclopedia of traditi
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Phytochemical compounds play a crucial role in determining the therapeutic potential of plant species and significantly contribute to their ability to resist environmental stress factors, whether biotic or abiotic. Based on the specific presence of such bioactive molecules, plant genera are often classified into various medicinal categories such as anti-inflammatory, anti-cancer, anti-diarrhoeal, and anti-stomachic plants. Among them, the family Convolvulaceae, which encompasses the genus Distim
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Written by Mariana Ganea
Published on Vol 3 , 2023
Infections caused by Candida species account for a significant proportion of fungal infections affecting the vaginal mucosa. Traditional antifungal treatments have shown limited efficacy, which has led to the search for alternative products based on plant-derived extracts, which are often more effective and non-toxic according to existing research. Our research focused on the extraction of essential oil from Origanum vulgare L. and the evaluation of its antimicrobial properties, known for its hi
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The influence of ABCB1 and CES1 genetic variants on dabigatran plasma exposure is still uncertain. This investigation aimed to quantitatively evaluate how these polymorphisms affect dabigatran ester concentrations in healthy Chinese participants using a population pharmacokinetic (PopPK) framework. A total of 1,926 PK samples obtained from 123 healthy volunteers who received 150 mg of oral dabigatran under either fasting or fed conditions were examined through a PopPK analysis. The data were bes
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The University of Florida’s Precision Medicine Program (PMP) centers its efforts on progressing pharmacogenomics (PGx) to enhance patient outcomes. The UF PMP, working together with the UF Health Pathology Laboratory (UFHPL), leveraged HL7 standards to embed PGx data within Epic’s Genomic Module, thereby strengthening the clinical handling and application of pharmacogenomic information." A major advancement in the Genomic Module is its use of genomic indicators, which highlight clinically releva
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Written by Sarah Mitchell
Published on Vol 3 , 2023
This work explores how Paromomycin influences SUMOylation-associated signaling in glioblastoma (GBM), with a particular focus on its inhibitory action on HDAC1. SUMOylation-related genes linked to GBM outcomes were screened using TCGA and GTEx datasets. Molecular docking predicted Paromomycin as a likely HDAC1 inhibitor. Functional experiments in U-251MG GBM cells—including CCK8 viability assays, qRT-PCR, and immunofluorescence—were conducted to evaluate its impact on SUMOylation gene activity,
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Adverse drug reactions (ADRs) continue to challenge healthcare systems worldwide, largely due to genetic differences in drug-metabolizing enzymes across populations. To address this, we conducted a comprehensive pharmacogenomic (PGx) survey of the South Korean (SKR) population, focusing on 21 clinically relevant pharmacogenes. Whole genome sequencing (WGS) was performed on 396 individuals, including healthy volunteers (n = 99), patients with chronic diseases (n = 95), and cancer patients with co
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Pharmacogenetic testing is increasingly used to guide clinicians in selecting medications tailored to a patient’s genetic profile. Although various government-supported organizations aim to establish standardized guidelines for testing and interpretation, adherence to these best practices is often inconsistent. Many pharmacogenetic testing companies rely on proprietary methods for analyzing and reporting results, which can result in inconsistencies across companies and potential differences in h
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Written by Khalid Rahman
Published on Vol 3 , 2023
Lung adenocarcinoma (LUAD) ranks among the deadliest cancers worldwide, with metastasis representing the primary cause of mortality. Despite advancements in diagnosis and treatment, the processes enabling LUAD cells to infiltrate the blood-brain barrier remain largely unknown. Although genomic profiling has provided insight into primary tumors, the genetic determinants and clinical significance of metastasis in LUAD are still poorly characterized. This study aims to delineate genomic differences
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Written by Carlos Méndez
Published on Vol 3 , 2023
Pulmonary hypertension (PH) often results in right ventricular hypertrophy, contributing to higher mortality. This study investigates PH-associated metabolites and their influence on genomic alterations and post-translational modifications (PTMs) in cancer, while assessing the therapeutic potential of DHA and EPA in reducing oxidative stress and inflammation. Using Mendelian randomization on a cohort of 289,365 individuals, we explored the causal involvement of 1,400 metabolites in pulmonary hyp
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Arylamine N-acetyltransferase 2 (NAT2) exhibits a well-characterized genetic polymorphism in humans that influences the metabolism of drugs and xenobiotics. Recent research, including genome-wide association studies, has linked NAT2 genetic variants to varying risks of dyslipidemia and cardiometabolic disorders, indicating a potential previously unrecognized role for NAT2 in metabolic disease pathophysiology. Consistent with this, our recent work demonstrated that human NAT2 expression is differ
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