Written by Ankita Awasthi
Published on Vol 4 , 2024
In the current study, the antioxidant potential of the extracts was evaluated by their ability to inhibit the autooxidation of epinephrine hydrochloride. The extracts derived from different parts of Moringa oleifera showed the highest antioxidant activity when extracted using a 40% alcohol-water mixture. The dry herb’s alcohol extract contains a range of bioactive compounds, including tannins (up to 30%), flavonoids (up to 5%), coumarins (up to 3.5%), phenolic acids (up to 6%), amino acids (up t
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Written by Doha Abdou Mohamed
Published on Vol 4 , 2024
Kumquat, also known as Japanese orange, is recognized as the smallest species in the citrus family. This plant thrives in warmer climates, where it produces an abundant yield of sweet fruits. Beyond its nutritional value, kumquat is regarded for its protective health benefits. Considering the essential role of the liver in executing various metabolic activities, such as nutrient absorption and processing, the current study was designed to investigate the protective and histological effects of ku
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Written by Gustavo Roberto Villas Boas
Published on Vol 4 , 2024
Melilotus officinalis (M. officinalis) is widely known for its anti-inflammatory, antioxidant, anticonvulsant, and anti-anxiety properties. The present study focused on evaluating the antidepressant potential of the ethanolic extract of M. officinalis fruit in a murine model. To assess toxicity, the Loreck method was used to determine the acute toxicity of the extract. Adult male mice were treated with fluoxetine, saline, or the ethanolic extract of M. officinalis. Behavioral assessments, includ
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Written by Mariana Ganea
Published on Vol 4 , 2024
Magnolia officinalis , a tree known for its bark, leaves, and flowers, contains phytochemicals that have garnered significant attention in recent research. Modern medicine increasingly incorporates plant extracts, rich in various classes of phytochemicals, either as replacements for traditional treatments or as complementary additions to enhance efficacy and minimize side effects. This study focuses on the extraction of oil from the leaves of M. officinalis, which was analyzed using GC-MS, revea
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Written by Attilio Anzano
Published on Vol 4 , 2024
This study investigated the in vitro anti-obesity effects of Anethum graveolens L. (Apiaceae) dill seed cake (DSC). DSC is a valuable source of dietary fiber, proteins, lignans, and phenolic compounds, all of which contribute to managing dyslipidemia, metabolic disorders, and obesity. DSC, extracted as a byproduct after oil removal, was subjected to physicochemical evaluation and lignan profiling using HPLC. In addition, its potential was analyzed by determining the hydrolysis rate and enzymatic
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Written by Cheickna Cissé
Published on Vol 4 , 2024
This research aimed to document the medicinal plants traditionally used for childhood cough treatment and to analyze the phytochemical composition of the two most frequently utilized species (Ceiba pentandra and Sericanthe chevalieri). An ethnobotanical survey was conducted in the Bamako markets, interviewing traditional herbal vendors. Phytochemical analysis was performed using standard colorimetric reactions and precipitation tube tests. Flavonoid content was determined with aluminum trichlori
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Written by Basiru Olaitan Ajiboye
Published on Vol 4 , 2024
This study investigated the therapeutic effects of flavonoid-rich Hibiscus sabdariffa L. leaf extracts in rats with streptozotocin-induced diabetes. The study evaluated various biochemical parameters, including markers of redox stress, inflammation, pancreatic tissue histology, insulin levels, purinergic enzyme functions, lipase activity, and homeostasis models for β-cell function and insulin resistance (HOMA-β, HOMA-IR). The results showed that H. sabdariffa extracts significantly (P < 0.05) al
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Written by T'yanna Montague
Published on Vol 4 , 2024
This study aimed to investigate the effectiveness of herbal treatments for stretch marks by conducting a detailed literature review and a survey to assess the knowledge and perceptions of pharmacy students. This research aimed to address the gaps in understanding and attitudes about stretch marks and their treatment options. A total of 40 first-year pharmacy students participated in the survey, which consisted of two parts: one focused on knowledge and the other on opinions, alongside demographi
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Pharmacogenetics (PGx) focuses on examining and applying how genetic variability between individuals affects medication outcomes. By analyzing a patient’s variation in genes linked to drug processing, PGx testing offers the potential to customize treatment in primary care and move beyond the traditional generalized prescribing model. In psychiatry, the use of PGx has produced encouraging findings, demonstrating improvements in therapeutic success as well as reductions in drug toxicity and advers
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Written by Thandeka Moyo
Published on Vol 4 , 2024
Lung adenocarcinoma (LUAD), the predominant form of lung malignancy, is associated with unfavorable clinical outcomes. Disulfidptosis, a recently described programmed cell-death mechanism, arises from excessive disulfide accumulation and disruption of the actin cytoskeleton. This work sought to pinpoint lncRNAs linked to disulfidptosis and to construct a disulfidptosis-associated lncRNA signature capable of forecasting LUAD prognosis and therapeutic responsiveness. RNA-seq profiles and clinical
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Written by Victor Hernandez
Published on Vol 4 , 2024
The discipline of pharmacogenetics (PGx) offers substantial potential for advancing individualized healthcare by tailoring drug therapy to a patient’s genetic profile. Although PGx provides clear clinical advantages, its broader adoption is still restricted by financial, ethical, and organizational obstacles within our healthcare system. To evaluate the influence of pharmacogenetic testing, we conducted a retrospective review of anonymized electronic health record data from a heterogeneous patie
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Toxic responses to fluoropyrimidines frequently stem from variations in DPYD, the gene coding for dihydropyrimidine dehydrogenase (DPD). Identifying DPYD variants allows clinicians to individualize treatment to lower the risk of fluoropyrimidine-associated adverse effects while still achieving effective drug exposure. A multiplex qPCR test was created in-house to detect six DPYD polymorphisms. This assay was offered prospectively to every patient beginning fluoropyrimidine therapy at the BC Canc
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Written by Noura Al Harbi
Published on Vol 4 , 2024
Compared with earlier epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), osimertinib delivers superior therapeutic activity and produces fewer grade 3 or higher adverse drug reactions (ADRs) in individuals with advanced non-small cell lung cancer (NSCLC) carrying epidermal growth factor receptor (EGFR) mutations. Nonetheless, treatment responses to this agent have been shown to differ among ethnic groups. For this reason, additional investigation is required to determine ho
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5-Fluorouracil (5-FU) is a commonly employed chemotherapeutic agent in multiple cancers, including hepatocellular carcinoma (HCC). Understanding why some HCC cases respond poorly or are resistant to 5-FU is essential for advancing precision oncology and optimizing treatment strategies. We applied Weighted Gene Co-expression Network Analysis (WGCNA) on gene expression data from the GDSC2 cancer cell line collection to detect 5-FU-related co-expression modules and hub genes. Based on these hub gen
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Pharmacogenomics (PGx) examines how genetic differences between individuals influence medication outcomes, creating the possibility of customizing drug dosing for each person. Existing focused PGx testing approaches primarily rely on microarrays, PCR-based systems, or short-read sequencing technologies. While these methods are effective for detecting single-nucleotide variants (SNVs) and insertion/deletion events (INDELs), they are not suitable for identifying large structural alterations or for
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Written by Sergei Ivanov
Published on Vol 4 , 2024
Bladder cancer represents a frequently encountered urologic malignancy and is linked to considerable morbidity and mortality. Although immunotherapy has become an important therapeutic approach, patient responses vary widely. Altered glycosylation has been associated with cancer development and immune modulation. Nevertheless, an integrated view of how glycosylation contributes to bladder cancer progression and its clinical relevance remains insufficiently defined. A training cohort was generate
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Written by Joseph Okello
Published on Vol 4 , 2024
Responses to antiseizure medications (ASM) vary widely from one individual to another, both in terms of benefit and adverse reactions. Genetic differences are believed to play a meaningful role in shaping these outcomes. Valproic acid (VPA), a commonly prescribed ASM, is influenced by numerous pharmacogenetic elements. Yet, unlike agents such as carbamazepine or phenytoin, the amount of evidence linking VPA to specific genetic variants remains limited. This study was therefore designed to invest
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Written by Bekzat Karimov
Published on Vol 4 , 2024
Dihydropyrimidine dehydrogenase (DPD), encoded by the DPYD gene, is the key enzyme regulating the breakdown of fluoropyrimidines (FPs). Variants in DPYD substantially alter DPD function and are firmly established predictors of FP-related adverse reactions. Four specific DPYD polymorphisms—rs3918290, rs55886062, rs67376798, and rs75017182—are incorporated into genotype-guided FP dosing recommendations and are advised by the European Medicines Agency (EMA) for testing prior to therapy. In Greece,
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Written by Artem Shevchenko
Published on Vol 4 , 2024
Patients with cancer encounter a heightened short-term likelihood of cardiovascular complications, whereas individuals suffering an acute myocardial infarction (AMI) tend to show an increased rate of cancer diagnoses. With clinical resources often limited, pinpointing overlapping biomarkers provides a practical and economical strategy for risk evaluation, reducing the need for numerous independent diagnostic procedures. Consequently, recognizing biomarkers that simultaneously relate to cancer su
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Written by Isabelle Laurent
Published on Vol 4 , 2024
Research has shown that the extract from Wedelia chinensis improves the outcomes of prostate cancer therapy. This investigation examined genes with altered expression in the 22RV1 prostate cancer cell line exposed to W. chinensis extract, utilizing data retrieved from the Gene Expression Omnibus (GEO), followed by gene ontology and pathway enrichment analyses. Expression data from the series GSE100224 were evaluated with GEO2R. Key genes showing differential expression were investigated through
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COVID-19 is a respiratory illness commonly associated with an inflammatory response that extends beyond lung symptoms and impairs blood clotting mechanisms. Hydroxysafflor yellow A, a key bioactive compound isolated from the florets of Carthamus tinctorius, is recognized as a potential therapeutic agent due to its combined anti-inflammatory and anticoagulant actions. Hence, this investigation assessed the influence of ethanol extract from C. tinctorius administered alongside dexamethasone on mar
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Written by Lucia Novakova
Published on Vol 4 , 2024
Rutin, a lipophilic flavonoid of natural origin, occurs in various vegetables, citrus fruits, and drinks. The purpose of this research is to examine the metabolic routes of rutin within human senescent stromal cells. Datasets were obtained from the Gene Expression Omnibus (GEO) repository and initially processed with GEO2R to detect significantly differentially expressed genes (DEGs). These significant DEGs underwent protein-protein interaction (PPI) network evaluation to pinpoint hub genes. Hub
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Written by Nguyen Thi Lan
Published on Vol 4 , 2024
Hot flashes rank as one of the most frequent and disruptive adverse reactions to androgen deprivation therapy (ADT) among men treated for prostate cancer. In the absence of an established standard therapy, more studies are needed to establish safe and effective management options. This randomized controlled trial involved prostate cancer patients on ADT who were randomly assigned to receive either chicory-fumitory syrup (derived from hydroalcoholic extracts of chicory and fumitory) or megestrol.
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Written by Fatima Zahra Amrani
Published on Vol 4 , 2024
Asthma represents a persistent inflammatory condition affecting the airways. Viola odorata has long been utilized in traditional medicine for managing various inflammatory disorders. This research sought to examine the potential anti-inflammatory actions of the aqueous extract derived from V. odorata in an experimental mouse model of asthma. A total of forty-eight female Balb/c mice were assigned to six groups, with eight mice per group. The normal control group was given distilled water, wherea
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Compared to primate species, the human diet features increased calories, higher protein levels, and the incorporation of cooking methods. This research sought to examine the variations between the human diet and the chimpanzee diet, which mainly includes fruits and vegetables, aiming to uncover both positive and negative impacts of human eating habits. Data on differentially expressed genes (DEGs) in mouse liver tissues following exposure to a “human cafeteria diet” versus a “chimpanzee diet” we
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Written by Kwame Boateng
Published on Vol 4 , 2024
Studies have underscored the favorable impact of coffee intake on maintaining blood glucose levels in humans. In contrast, metformin serves as the standard pharmacological treatment for type 2 diabetes. The present investigation aimed to examine potential roles for coffee either as an adjunct to metformin or as a standalone approach in managing type 2 diabetes. Proteomic information concerning the influence of caffeine and trigonelline—the two principal bioactive components in coffee—on alleviat
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