Written by Mohamed Mohey
Published on Vol 1 , 2021
One of the most common endocrine diseases in the general population is diabetes mellitus (DM). It is a major metabolic disease that leads to significant morbidity and mortality with micro- and macro-vascular consequences, making it one of the major public health concerns in a developing country. Chronic diabetes is not properly managed and often leads to cardiovascular problems and nephropathy. To a higher degree, research suggests that type 2 diabetes patients are a chronic inflammatory disease
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Written by Shmatenko Oleksandr
Published on Vol 1 , 2021
The management of wounds from many causes, such as surgical, purulent, or gunshot wounds, is still a major issue in modern times. Not only are treatment procedures advancing, but combat operations techniques have also been enhanced. The development of resistant microbes is also encouraged by the shift away from conventional wound care techniques. All of these make it more difficult to treat wounds and monitor their progression. This research aims to investigate the effects of the freezing proced
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Written by María del Rosario Hernández-Jerónimo
Published on Vol 1 , 2021
Due to the lack of clinical pharmacists in the health system, plasma drug quantitation is used in Mexico to assess dosage titration, compliance, and toxicity during the treatment of patients with antiepileptic medications such as valproic acid (VPA). However, pharmacokinetic principles are not taken into account. To provide the necessary recommendations, this study investigated the intrapatient relationship between dosage and plasma VPA concentrations in different age groups, assessed the effect
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Written by Alireza Ebadi Tabrizi
Published on Vol 1 , 2021
Overexpression of efflux pumps is a common mechanism of multidrug resistance (MDR), and antibiotic resistance genes are found in bacteria that are generally considered benign, which poses a risk. The global spread of bacterial infections and the increase in antibiotic resistance are two major problems that medical science is currently facing. One type of efflux pump that plays an important role in bacterial MDR is the ATP-binding cassette (ABC) transporter. ABC transporters hydrolyze ATP to faci
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Written by Khagga Bhavyasri
Published on Vol 1 , 2021
The present study aimed to investigate the RP-HPLC method for the determination of dapagliflozin and metformin HCl in bulk and combined formulation. For this purpose, the provided RP-HPLC approach was found to be straightforward, precise, specific, and cost-effective. The phase of stationary Chromatographic conditions was Phenomenex C18 250 x 4.6 mm. A 50:50 water: methanol ratio was employed as the fluid phase. The wavelength of observation was 230 nm, the diluent was water, and the flow rate w
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This research explored community pharmacists’ perspectives and the obstacles they encounter when delivering pharmaceutical care to pregnant women in Bulgaria. A cross-sectional online questionnaire was distributed to pharmacists in the Plovdiv region, featuring 18 Likert-scale items designed to capture their views and challenges related to this aspect of practice. Responses were obtained from 122 pharmacists. Nearly all participants (90%) believed that pharmacist-led care could significantly enh
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Bovine colostrum (BC), the first milk produced by cows postpartum, has been traditionally utilized in managing various human conditions, including infections, inflammatory disorders, and cancers. Emerging research highlights bovine lactoferrin and bovine antibodies as the primary bioactive components responsible for BC’s therapeutic effects. Consequently, BC has also been examined for its potential to offer short-term protection against COVID-19. Moreover, it holds promise as a source for peptid
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Written by Jasmine Singh
Published on Vol 1 , 2021
Upper gastrointestinal (GI) symptoms are commonly reported by patients visiting community pharmacies in Italy, yet their prior treatment history is often not well documented. This descriptive, cross-sectional study investigated the medication use of individuals experiencing upper GI symptoms who visited one of 20 participating community pharmacies over a 7-month period, using a structured questionnaire. Among 1,020 respondents, 62.1 percent had previously sought medical consultation. The most fr
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Chronic superficial gastritis (CSG) is a widespread digestive disorder with a complex and multifactorial pathogenesis. Jinhong tablet (JHT), a traditional Chinese medicine formulation, has shown efficacy in treating CSG, but the molecular mechanisms underlying its therapeutic effects remain poorly understood. In this study, we applied ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q/TOF-MS) to comprehensively profile the chemical com
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Written by Hiroshi Tanaka
Published on Vol 1 , 2021
Serum exhibits a highly complex composition, which poses challenges for discovering novel pharmacodynamic biomarkers through serum proteomics for disease prediction and diagnosis. Recent studies have shown that nanoparticles can effectively decrease the abundance of high-concentration proteins while enriching low-abundance proteins in serum. In this study, we synthesized silica-coated iron oxide nanoparticles and established a highly efficient and reproducible protein corona (PC)-based proteomic
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Atrial fibrillation (AF) is a progressive condition with significant health implications, where fibrosis plays a central role. This study aimed to evaluate the impact of adding mineralocorticoid receptor blockade to standard therapy in patients with AF after restoration of sinus rhythm, focusing on arrhythmia recurrence, hospitalizations, and changes in Galectin-3 levels as a fibrosis marker. We prospectively enrolled 101 consecutive patients (56 females; mean age 68.2 ± 7 years) with AF who had
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Written by Isabelle Dubois
Published on Vol 1 , 2021
Fexofenadine is widely employed for treating various allergic conditions, yet limited data exist regarding its pharmacokinetic variability and the quantitative determinants influencing it. This study sought to validate previously suggested genetic factors using population pharmacokinetic modeling of fexofenadine and to quantify the genetic contributions affecting its pharmacokinetic diversity. Polymorphisms in the organic-anion-transporting-polypeptides (OATP) 1B1 and 2B1 have been implicated in
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Written by Benjamin Miller
Published on Vol 1 , 2021
The automation of traditional Chinese medicine (TCM) manufacturing has advanced process analysis from offline to online modes. However, most existing online analytical technologies rely on spectroscopic methods, which still face difficulties in accurately identifying and quantifying individual compounds. In this study, we established a quality control (QC) system utilizing paper spray ionization miniature mass spectrometry (mini-MS) to monitor TCM production processes. This approach enabled, for
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The implementation of telepharmacy offers new opportunities for healthcare delivery and helps address the challenge of limited pharmacist availability. This study aimed to assess attitudes toward providing and utilizing telepharmacy services in Bulgaria. A total of 379 participants, predominantly healthcare professionals, took part, with an average age of 44.38 ± 12.39 years. Data were analyzed using IBM SPSS Statistics v.23. Over 90% of respondents reported using the Internet to search for heal
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Written by Elin Svensson
Published on Vol 1 , 2021
Community pharmacists play a key role in promoting safe and effective self-management of common skin conditions and providing educational support for clinician-prescribed therapies, thereby enhancing patient adherence. In this study, a semi-structured survey was conducted with 154 Italian community pharmacists to gather insights on their counseling practices regarding dermatological disorders. The findings offer a comprehensive overview of the frequency and approaches used in counseling within I
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Written by Sophia Davies
Published on Vol 1 , 2021
Glycyrrhizae Radix et Rhizoma, commonly known as Gan Cao (GC), is widely used in traditional Chinese medicine formulations for pneumonia management, yet its active pharmacological constituents in this context remain largely uninvestigated. Gan An He Ji oral liquid (GAHJ), a clinically used preparation composed of GC extracts and paregoric, was selected as a model compound to explore GC’s therapeutic components for pneumonia. In a clinical study, patients with pneumonia received GAHJ treatment fo
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Written by Thomas Jansen
Published on Vol 1 , 2021
In December 2019, a novel coronavirus, SARS-CoV-2, was first detected in Wuhan, Hubei Province, China. The virus quickly spread to multiple countries, with Italy, Spain, and the United States among the hardest hit. Consequently, in March 2020, the World Health Organization (WHO) officially declared COVID-19 a global pandemic. Despite timely interventions aimed at controlling the spread, the total number of confirmed cases has reached 119,452,269, with fatalities totaling 2,647,662. The pandemic
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