Volume 1 (2021)

One of the most common endocrine diseases in the general population is diabetes mellitus (DM). It is a major metabolic disease that leads to significant morbidity and mortality with micro- and macro-vascular consequences, making it one of the major public health concerns in a developing country. Chronic diabetes is not properly managed and often leads to cardiovascular problems and nephropathy. To a higher degree, research suggests that type 2 diabetes patients are a chronic inflammatory disease

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The management of wounds from many causes, such as surgical, purulent, or gunshot wounds, is still a major issue in modern times. Not only are treatment procedures advancing, but combat operations techniques have also been enhanced. The development of resistant microbes is also encouraged by the shift away from conventional wound care techniques. All of these make it more difficult to treat wounds and monitor their progression. This research aims to investigate the effects of the freezing proced

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Due to the lack of clinical pharmacists in the health system, plasma drug quantitation is used in Mexico to assess dosage titration, compliance, and toxicity during the treatment of patients with antiepileptic medications such as valproic acid (VPA). However, pharmacokinetic principles are not taken into account. To provide the necessary recommendations, this study investigated the intrapatient relationship between dosage and plasma VPA concentrations in different age groups, assessed the effect

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Overexpression of efflux pumps is a common mechanism of multidrug resistance (MDR), and antibiotic resistance genes are found in bacteria that are generally considered benign, which poses a risk. The global spread of bacterial infections and the increase in antibiotic resistance are two major problems that medical science is currently facing. One type of efflux pump that plays an important role in bacterial MDR is the ATP-binding cassette (ABC) transporter. ABC transporters hydrolyze ATP to faci

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The present study aimed to investigate the RP-HPLC method for the determination of dapagliflozin and metformin HCl in bulk and combined formulation. For this purpose, the provided RP-HPLC approach was found to be straightforward, precise, specific, and cost-effective. The phase of stationary Chromatographic conditions was Phenomenex C18 250 x 4.6 mm. A 50:50 water: methanol ratio was employed as the fluid phase. The wavelength of observation was 230 nm, the diluent was water, and the flow rate w

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