Issue 1 Volume 3 (2023)

Genetic alterations in the ALK gene occur in approximately 3-5% of cases of non-squamous non-small cell lung cancer (NSCLC). These rearrangements are critical in determining how cancer cells respond to treatment with ALK inhibitors. However, over time, some patients may develop resistance, leading to disease progression. In such cases, performing genetic analysis is crucial to detect new mutations that could be driving resistance, enabling healthcare providers to select the most appropriate next

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Breast cancer (BC) is the second leading cause of cancer-related deaths among women worldwide, and occasionally occurs in men. The majority of deaths related to breast cancer, over 90%, are due to delayed detection, which allows the disease to spread to other organs. The diagnostic process usually involves a biopsy, supported by imaging techniques such as MRI and CT scans, to confirm the diagnosis and guide treatment planning. This review examines various treatment strategies, including chemothe

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The focus of the present study was to evaluate the cytotoxic effects of novel peptide esters derived from galantamine—GAL-LEU and GAL-VAL—on the PC3 prostate cancer cell line. To assess the cytotoxicity of these compounds, the MTT assay, a method that quantifies cellular metabolic activity through the reduction of MTT to formazan, was used. PC3 cells were exposed to different concentrations (ranging from 1.875 μM to 30 μM) of the peptide esters in triplicate. The absorbance of the formazan produ

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Benign gallbladder disorders are frequently observed and generally resolve without long-term effects. However, some of these conditions are associated with an increased risk of gallbladder cancer, while others can lead to malignancy. This review aims to inform surgeons of the potential improvements in treatment strategies enabled by earlier recognition of GBC and to assist pathologists in refining histopathological assessments to reduce fatalities associated with delayed diagnoses. The immune ma

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Thiazolidin-4-ones exhibit a highly adaptable and privileged core structure, consisting of a five-membered heterocyclic ring with a sulfur atom and a cyclic amide bond. Recent research, especially in the last decade, has extensively explored the various biological activities of this scaffold, highlighting its potential therapeutic applications. Several key features, such as drug-likeness, compatibility for diversity-oriented synthesis, and sensitivity to the redox environment of tumors, make it

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Heliomycin, a compound obtained from the secondary metabolites of actinomycetes bacteria, was tested for its anticancer effects, with tamoxifen serving as the reference drug. Flow cytometry, cell cycle analysis, and apoptosis assays were performed, alongside real-time RT-PCR to evaluate gene expression. The expression of CK-19 was examined by immunocytochemistry, while cytopathological changes were observed using H&E staining and electron microscopy. The results of real-time PCR showed that HER-

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