Written by Chuan-Xiang Li-
Published on Issue 1 Vol 4, 2024
Accurate diagnosis of lesions and tumors in the salivary glands demands an in-depth knowledge of their complex cellular structure. These glands comprise various cell types, such as epithelial, ductal, mesenchymal, and myoepithelial cells, which together create a multifaceted architecture that complicates the diagnostic process. In addition, external influences such as infections, viruses, and genetic mutations can contribute to changes in salivary gland function and pathology. Consequently, unde
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Written by S. P. Ashwin
Published on Issue 1 Vol 4, 2024
Oxidative stress arises when the generation of free radicals exceeds the capacity of the body’s antioxidant defense and repair mechanisms, leading to unchecked oxidative damage. These reactive oxygen species (ROS) significantly contribute to molecular degradation, promote neoplastic alterations at the cellular level, and exert a profound impact on all phases of the cancer development process. In the Indian subcontinent, oral potentially malignant disorders such as leukoplakia and oral submucous
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Written by Joanna Rypel
Published on Issue 1 Vol 4, 2024
Adenoid cystic carcinoma (ACC) of the breast represents a rare basal-like subtype that can exhibit cribriform, solid, tubular, or trabecular architectural features. Histologically, breast ACC exhibits a unique arrangement consisting of both epithelial and myoepithelial cells, mirroring the structure seen in its salivary gland counterpart. This report highlights an unusual presentation of breast ACC characterized by a cribriform and trabecular growth pattern. Although imaging techniques are valua
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Written by Abeer Saeed Hassan Osluf
Published on Issue 1 Vol 4, 2024
Persistent fetal vasculature (PFV), or persistent hyperplastic primary vitreous (PHPV), is a rare condition involving abnormal development of the vitreous and retinal structures. This case report highlights a premature male infant, born at 35 weeks gestation weighing 2.135 kg, who presented with PFV, hydrocephalus, and developmental delay. The infant underwent an emergency cesarean section due to fetal distress. Antenatal ultrasound revealed significant ventriculomegaly (43 mm). Postbirth, the i
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Written by Abdulrahman Hakami
Published on Issue 1 Vol 4, 2024
Pulmonary carcinosarcoma (PCS) is an uncommon and aggressive cancer, characterized by a combination of epithelial and sarcomatous tissue components. It is responsible for less than 1% of all lung tumors and usually affects older male smokers. However, the clinicopathological features and biological behavior of PCS remain insufficiently explored. This study aimed to shed light on these aspects. A total of eight patients with pathologically confirmed PCS were included in this retrospective study.
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Written by Maria Lopez-Ramos
Published on Issue 1 Vol 4, 2024
Several studies have reported that certain cannabinoid derivatives may affect prostate cancer progression. However, their specific actions on the androgen receptor and the 5α-reductase enzyme remain ambiguous, likely due to the structural variability among cannabinoid compounds. This computational investigation aimed to explore the theoretical interactions of 20 distinct cannabinoid derivatives (identified as compounds 1 through 20) with the androgen receptor and the 5α-reductase enzyme, using t
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