Written by Gary J. Farkas
Published on Vol 5 Issue 1, 2025
This paper reviews the increased cardiovascular risks associated with spinal cord injury (SCI), focusing on the pathophysiological mechanisms, clinical manifestations, and both immediate and long-term effects. It identifies several potential risk factors for cardiovascular diseases post-SCI, including reduced physical activity, low HDL cholesterol levels, higher body fat percentage, poor glucose tolerance, insulin resistance, psychosocial influences, and emerging risk factors associated with SCI
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Written by Maria Możdżan
Published on Vol 5 Issue 1, 2025
Mitral valve prolapse (MVP), which affects approximately 2–3% of the population, is often benign but may be associated with a higher incidence of ventricular arrhythmias (VA) and sudden cardiac death (SCD). This study aimed to highlight the incidental detection of MVP among SCD cases and to investigate the associated histopathological features. In addition, we investigated the potential risk of VA in MVP patients by assessing heart rate variability (HRV) and heart rate turbulence (HRT). In 2021,
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Written by Codruta Diana Petchesi
Published on Vol 5 Issue 1, 2025
Long QT syndrome type I is an autosomal dominant disorder caused by a heterozygous loss-of-function mutation in the KCNQ1 gene, located on chromosome 11p15. This chromosomal region is subject to genomic imprinting and is also implicated in Beckwith-Wiedemann syndrome. This report describes a female patient with inherited long QT syndrome type I, present in her mother and sister, concurrently with Beckwith-Wiedemann syndrome due to hypomethylation in the imprinting control region 2 (IC2). Methyla
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Written by Olesya Olegovna Kalion
Published on Vol 5 Issue 1, 2025
Thyroid surgery is commonly indicated for a variety of clinical reasons, with one of the primary purposes being the diagnostic evaluation of thyroid tumors using fine needle biopsy. This technique continues to represent the gold standard in the evaluation of thyroid nodules. In recent years, especially over the past decade and a half, Russia has experienced a significant increase in the incidence of thyroid carcinoma. This upward trend is largely associated with the advancement and widespread im
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Written by Joanne Traeger-Synodinos
Published on Vol 5 Issue 1, 2025
The presence of alpha thalassemia and levels of hemoglobin F (HbF) significantly influence the clinical presentation of sickle cell disease (SCD) across different populations. This study was conducted to investigate the effects of these two factors on SCD patients in northern Iraq. A total of 74 patients with sickle/β0 thalassemia or sickle cell anemia, with a mean age of 16 years, participated in the study, of which 56.8% were male. Comprehensive clinical evaluations and lab tests were performe
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Written by Inês Morais
Published on Vol 5 Issue 1, 2025
Coronavirus disease (COVID-19) is caused by a novel strain of coronavirus, while malaria is a parasitic infection triggered by Plasmodium protozoans, transmitted via Anopheles mosquitoes. The simultaneous occurrence of both malaria and COVID-19, and their interplay, remains poorly documented. This study aimed to investigate the correlation between malaria and COVID-19, focusing on the disease’s severity, treatment strategies, and clinical outcomes. The research was conducted in isolation centers
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Written by Henrique Silva
Published on Vol 5 Issue 1, 2025
Biofilm accumulation on implantable silicone-based medical devices remains a critical challenge for healthcare systems. To address this, we introduce a novel, multi-modal strategy to preemptively inhibit bacterial colonization. This study investigates the efficacy of plasma-synthesized nanostructured metallic silver coatings—specifically three distinct geometries termed “Sharp blades,” “Thick blades,” and “Leaves”—immobilized onto stretchable substrates via a plasma-polymerized penta-fluoropheny
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Written by Hassan Ali
Published on Vol 5 Issue 1, 2025
Medicinal plants are commonly used for malaria treatment across various regions of Nigeria, and exploring these plants can lead to the discovery of new therapeutic agents. This study investigated the antiplasmodial properties of selected plants traditionally used to treat malaria in Nsukka, Enugu State, Nigeria. Leaves from three plants—Cucurbita pepo, Hibiscus rosa-sinensis, and Pennisetum purpureum—were collected, and two types of extracts were prepared from each: 70% ethanol and a 1:1 mixture
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Written by Nikola Stojanov
Published on Vol 5 Issue 1, 2025
To undertake a quantitative analysis of the existing literature addressing the role of traditional Chinese medicine in managing COVID‑19. Research articles concerning the prevention and treatment of COVID‑19 using traditional Chinese medicine (TCM), published up to September 19, 2021, were collected from the Web of Science database. Data analysis was performed with the Bibliometrix R 4.0 software package to assess publication countries, research institutions, journals, citation metrics, and keyw
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Written by Sanjay Mehta
Published on Vol 5 Issue 1, 2025
This study aims to develop a nomogram to accurately predict anxiety symptoms in postgraduate medical students, enabling early identification of high-risk individuals and provision of targeted interventions. A convenience sampling method was employed to select participants for a case-control study, comprising 126 individuals with anxiety symptoms as the case group and 774 age- and gender-matched individuals without anxiety symptoms as the control group. Multivariable logistic regression analysis
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Written by Abel Tesfahun
Published on Vol 5 Issue 1, 2025
Multidrug resistance (MDR) in pathogenic bacteria has emerged as a significant clinical challenge. Targeting quorum sensing (QS), which regulates bacterial virulence, represents a promising strategy for combating MDR infections. In this study, we aimed to evaluate the anti-quorum sensing potential of selected medicinal plants against bacterial pathogens, alongside in silico interactions of their bioactive phytocompounds with QS and biofilm-associated proteins. Based on ethnopharmacological relev
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Written by Luis Herrera
Published on Vol 5 Issue 1, 2025
In Tanzania, the trade of medicinal plant products has developed into a complex rural-to-urban supply network over time, influenced by changes in business environments at both macro and micro levels. At the macro level, shifts in policy and regulatory frameworks have played a significant role, while at the micro level, traders’ adaptive responses to these changes and to pandemics have shaped trade practices. Despite this, there is limited documentation on how traders have reacted to these evolvi
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Written by Farah Siddiqui
Published on Vol 5 Issue 1, 2025
Self-medication with conventional and/or herbal medicines during pregnancy may pose significant risks, potentially leading to health complications or even death for both the mother and the fetus. The present study aimed to assess the prevalence of self-medication and identify the factors influencing the use of conventional and herbal medicines among pregnant women attending antenatal care (ANC) follow-up at Mizan-Tepi University Teaching Hospital (MTUTH) in Southwest Ethiopia. A cross-sectional
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Written by Martin Svendsen
Published on Vol 5 Issue 1, 2025
Online learning has emerged as an essential component of education globally, particularly following the COVID-19 pandemic. This study aimed to evaluate medical students’ perceptions of online learning, as well as their self-reported readiness and the challenges they faced during the pandemic." A web-based, cross-sectional survey was administered to students enrolled in Pharmacy, Doctor of Pharmacy, Medicine, Nursing, Dentistry, and Veterinary Medicine programs at both public and private universi
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Written by Rashid Al Shehri
Published on Vol 5 Issue 1, 2025
Road traffic injuries remain a leading cause of preventable death and disability globally. To improve risk stratification and resource allocation, various prognostic scoring tools have been introduced over the years. This study was conducted to assess the ability of the modified Rapid Emergency Medicine Score (mREMS) to predict in-hospital mortality in victims of road traffic crashes and to determine how its performance compares to that of two established trauma scores: the Revised Trauma Score
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Written by Alejandro Fuentes
Published on Vol 5 Issue 1, 2025
Hypothalamic dysfunction can lead to irregularities in glucose metabolism, a major contributor to the development of type 2 diabetes mellitus (T2DM). The interplay between autophagy and apoptosis is critical for cellular and tissue balance, and this process may become impaired in T2DM. Given that propionic acid (PA) has neuroprotective properties, this study aimed to explore its impact on the regulation of the apoptosis/autophagy balance in the ventromedial hypothalamus (VMH) of rats with type 2
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Written by Daniel Mwangi
Published on Vol 5 Issue 1, 2025
A series of newly synthesized mono-5-isoxazolidine and bis(5-isoxazolidine) derivatives were obtained as bicyclic cycloadducts. These compounds were rationally designed and constructed through a 1,3-dipolar cycloaddition between nitrones and 3,9-divinyl-2,4,8,10-tetraoxaspiro(5.5)undecane, with the goal of discovering new antimicrobial and antioxidant agents. The resulting isoxazolidines were thoroughly characterized using FT-IR, ¹³C-NMR, and ¹H-NMR spectroscopic techniques. The physicochemical
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