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Interdisciplinary Research in Medical Sciences Specialty

2025 Volume 5 Issue 1

Exploring Risk Factors and Preventive Strategies for Cardiovascular Dysfunction Following Spinal Cord Injuries: A Comprehensive Literature Review


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  1. Department of Physical Medicine and Rehabilitation, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

  2. The Miami Project to Cure Paralysis, Department of Neurological Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

     
  3. School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  4. School of Osteopathic Medicine, Rowan-Virtua University, Stratford, NJ 08084, USA.
  5. DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Knoxville, TN 37752, USA.
  6. Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

     
  7. Department of Physical Medicine and Rehabilitation, The Ohio State University, Columbus, OH 43210, USA.
  8. Department of Orthopaedics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
  9. Centre for Trauma Science Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  10. Jerry M. Wallace School of Osteopathic Medicine, Campbell University, Lillington, NC 27546, USA.

     
  11. Department of Physical Medicine and Rehabilitation, School of Medicine, MetroHealth Rehabilitation Institute, Case Western Reserve University, Cleveland, OH 44106, USA.
  12. Louis Calder Memorial Library, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

     
Abstract

This paper reviews the increased cardiovascular risks associated with spinal cord injury (SCI), focusing on the pathophysiological mechanisms, clinical manifestations, and both immediate and long-term effects. It identifies several potential risk factors for cardiovascular diseases post-SCI, including reduced physical activity, low HDL cholesterol levels, higher body fat percentage, poor glucose tolerance, insulin resistance, psychosocial influences, and emerging risk factors associated with SCI. Appropriate nutritional counseling and intervention are critical because individuals with SCI often consume insufficient nutrition. Screening for cardiovascular risk factors and assessing the global risk for coronary heart disease are essential steps in prevention. Research suggests that people with chronic SCI are more likely to experience poor glucose tolerance, insulin resistance, and hyperinsulinemia. Key management strategies for these patients involve weight control, dietary changes, physical activity, and blood sugar management. Successful prevention of cardiovascular disease requires the active involvement of both patients and healthcare providers.


How to cite this article
Vancouver
Farkas GJ, Caldera LJ, Hodgkiss DD, Mitchell JR, Pelaez TF, Cusnier MA, et al. Exploring Risk Factors and Preventive Strategies for Cardiovascular Dysfunction Following Spinal Cord Injuries: A Comprehensive Literature Review. Interdiscip Res Med Sci Spec. 2025;5(1):1-9. https://doi.org/10.51847/JQgtpyhvdR
APA
Farkas, G. J., Caldera, L. J., Hodgkiss, D. D., Mitchell, J. R., Pelaez, T. F., Cusnier, M. A., Cole, A. J., Daniel, S. G., Farrow, M. T., Gee, C. M., et al. (2025). Exploring Risk Factors and Preventive Strategies for Cardiovascular Dysfunction Following Spinal Cord Injuries: A Comprehensive Literature Review. Interdisciplinary Research in Medical Sciences Specialty, 5(1), 1-9. https://doi.org/10.51847/JQgtpyhvdR
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